41417-68-9

Upstream product

• 67-56-1 methanol 
• 696-29-7 (1-methylethyl)-cyclohexane 
• 4630-82-4 methyl cyclohexylcarboxylate 
• 1127-07-7 trans-isopropyl-cyclohexanecarboxylic acid 

Downstream Products

• 851537-46-7 4-(1-isopropyl-cyclohexanecarbonyl)-benzoic acid 
• 851537-49-0 4-(1-isopropyl-cyclohexanecarbonyl)-benzoic acid methyl ester 
• 851537-43-4 1-isopropylcyclohexyl 4-cyanophenyl ketone 
• 851537-37-6 (4-fluoro-phenyl)-(1-isopropyl-cyclohexyl)-methanol 
• 851537-40-1 1-isopropylcyclohexyl 4-fluorophenyl ketone 
• 41417-88-3 Methyl-1-isobutylcyclohexancarboxylat 

Relevant academic research and scientific papers

Photochemistry of 1-isopropylcycloalkyl aryl ketones: Ring size effects, medium effects, and asymmetric induction

(Chemical Equation Presented) The n = 0, 1, and 2 ketones shown above undergo Yang photocyclization in solution, but only the n = 1 analogues react this way in the solid state. Based on X-ray crystallography, these differences in reactivity are attributed to an unusually large distance for 1,4-hydroxybiradical cyclization in the solid state for the n = 0 and 2 ring systems, which leads to predominant reverse hydrogen transfer (rht). Enantiomeric excesses of up to 99% can be achieved in the case of the n = 1 system through the use of the solid-state ionic chiral auxiliary method of asymmetric synthesis.

Alkane Functionalization on a Preparative Scale by Mercury-Photosensitized Cross-Dehydrodimerization

Alkanes can be functionalized with high conversions and in high chemical and quantum yields on a multigram scale by mercury-photosensitized reaction between an alkane and alcohols, ethers, or silanes to give homodimers and cross-dehydrodimers.The separation of the product mixtures is often particulary easy because of a great difference in polarity of the homodimers and cross-dimers.It is also possible to bias the product composition when the ratio of the components in the vapor phase is adjusted by altering the liquid composition.This is useful either to maximize chemical yield or to ease separation by favoring the formation of the most easily separated pair of compounds.The mechanistic basis of the reaction is discussed and a number of specific types of syntheses, for example of 2,2-disubstituted carbinols, are described in detail.The selectivity of cross-dimerization is shown to exceed that for homodimerization and reasons are discussed.Relative reactivities of different compounds and classes of compound are MeOHp-dioxanecyclohexane1,3,5-trioxacyclohexaneethanolisobutaneTHFEt3SiH.The observed selectivities generally parallel those for homodimerization, reported in the preceding paper, but certain differences are noted, and reasons for the differences are proposed.The bond-dissociation energy of Et3SiH is estimated from the reactivity data to be 90 kcal/mol.Eleven new carbinols are synthesized.

Compositions having a physiological cooling effect

Alkyl-substituted methanols are disclosed having the property of stimulating the cold receptors of the nervous system of the human body to produce a cold sensation and are used for this purpose in a variety of edible and topical preparations.