41420-93-3

Usage

Uses

Used in Pharmaceutical Industry:
2-(3-chlorophenyl)-5-Methyl-1,3,4-oxadiazole is used as a building block for the development of new drugs. Its unique structure and properties allow it to be incorporated into various drug molecules, potentially enhancing their therapeutic effects and targeting specific diseases.
Used in Agrochemical Industry:
2-(3-chlorophenyl)-5-Methyl-1,3,4-oxadiazole is used as a key component in the synthesis of pesticides. Its chemical properties and structural features make it suitable for creating effective and targeted agrochemicals, contributing to improved crop protection and yield.
Used in Chemical Synthesis:
2-(3-chlorophenyl)-5-Methyl-1,3,4-oxadiazole is used as an intermediate in the synthesis of various organic compounds. Its versatile structure allows it to be a valuable building block in the creation of a wide range of chemical products, including dyes, polymers, and other specialty chemicals.

Upstream product

• 127-19-5 N,N-dimethyl acetamide 
• 1673-47-8 3-chlorobenzhydrazide 
• 1445-45-0 Trimethyl orthoacetate 
• 41421-28-7 5-(m-chlorophenyl)tetrazole 
• 108-24-7 acetic anhydride 

Relevant academic research and scientific papers

TiCl4 mediated facile synthesis of 1,3,4-oxadiazoles and 1,3,4-thiadiazoles

An efficient method for the synthesis of 2,5-disubstituted 1,3,4-oxadiazoles and 1,3,4-thiadiazoles has been developed. Various hydrazides or thionyl hydrazides readily react with DMA derivatives in the presence of TiCl4 as a catalyst to afford the desired products. This protocol provides a simple and economical procedure that affords the target products with good yields and wide substrate scope.

Microwave promoted one-pot synthesis of 2-aryl substituted 1,3,4-oxadiazoles and 1,2,4-oxadiazole derivatives using Al3+-K10 clay as a heterogeneous catalyst

An efficient, inexpensive method is developed for the one-pot synthesis of 2-aryl substituted 1,3,4-oxadiazoles and 1,2,4-oxadiazoles starting from acid hydrazides and trimethyl orthoformate under solvent-free, microwave conditions using a reusable Alsup

TETRAZOLES IN THE SYNTHESES OF 1,3,4-OXADIAZOLES

Various variants of cleavage of tetrazoles to form 1,3,4-oxadiazoles are examined.The mechanisms and synthetic potentialities of these reactions are discussed.

TETRAZOLES. XXX. ACYLATION OF 5-SUBSTITUTED TETRAZOLES

The acylation of 5-substituted tetrazoles with carboxylic acid chlorides and anhydrides gives rise to 2,5-disubstituted 1,3,4-oxadiazoles in high yields.The reaction goes without the addition of organic bases at 100-105 deg C.The acylation of 5-substituted tetrazoles in a two-phase organic solvent-water system in presence of tetrabutylammonium bromide yields N-acyltetrazoles, which are converted into 2,5-disubstituted 1,3,4-oxadiazoles on thermolysis.