41422-62-2Relevant academic research and scientific papers
Discovery of new 2, 5-disubstituted 1,3-selenazoles as selective human carbonic anhydrase IX inhibitors with potent anti-tumor activity
Angeli, Andrea,Trallori, Elena,Ferraroni, Marta,Di Cesare Mannelli, Lorenzo,Ghelardini, Carla,Supuran, Claudiu T.
, p. 1214 - 1222 (2018)
A series of disubstituted selenazole derivatives was synthetized and evaluated as carbonic anhydrase (CA, EC 4.2.1.1) inhibitors against the human (h) isoforms hCA I, II, IV, VA, VB and IX, involved in a variety of diseases including glaucoma, retinitis pigmentosa, epilepsy, arthritis and tumors. The investigated compounds showed potent inhibition against the tumor-associated transmembrane hCA IX, with KIs in the subnanomolar – low nanomolar range, and were evaluated for their effects on cell viability against the human prostate (PC3) and breast (MDA-MB-231) cancer cell lines, showing effective anti-tumor activity. These selenazoles are interesting leads for the development of new, isoform-selective CA IX inhibitors.
Facile synthesis of mixed O, S or Se bearing hexasubstituted benzenes and their potential as Cu(ii) ion probe
Kumar, Abhishek,Yadav, Mantesh K.,Singh, Jagriti,Singh, Jai Deo,Butcher, Ray J.
, p. 5627 - 5636 (2019/05/10)
The present study offers a facile route for the synthesis of unsymmetrical hexasubstituted benzenes bearing alternate heteroatoms (O, S and Se) with the formula [1,3,5-(RSeCH2)3-2,4,6-(R′ECH2)3C6] (E
Synthesis and conformational analysis of 2-arylseleno-1,3-dithianes. Crystal and molecular structure of 2-(4-methoxyphenylseleno)- and 2-(4-trifluoromethylphenylseleno)-1,3-dithiane
Pinto, B. Mario,Sandoval-Ramirez, Jesus,Sharma, R. Dev,Willis, Anthony C.,Einstein, Frederick W. B.
, p. 732 - 738 (2007/10/02)
The synthesis of 2-(4-methoxyphenylseleno)-1,3-dithiane 3 and 2-(4-trifluoromethylphenylseleno)-1,3-dithiane 5 from 2-chloro-1,3-dithiane 1 and the corresponding sodium arylselenolates is described.Nuclear magnetic resonance spectroscopic investigation of
