4143-50-4

Usage

InChI:InChI=1/C7H15NS2/c1-3-5-8(6-4-2)7(9)10/h3-6H2,1-2H3,(H,9,10)

Upstream product

• 75-15-0 carbon disulfide 
• 142-84-7 di-n-propylamine 
• 7631-95-0 sodium molybdate dihydrate 

Downstream Products

• 138144-74-8 C₁₉H₂₄ClNS₂Te 
• 78741-99-8 C₂₀H₂₂Cl₃N₃S₂ 
• 2556-42-5 tetrapropyl thiuram disulfide 
• 14354-08-6 copper(II) di-n-propyldithiocarbamate 
• 428507-04-4 [(PhCH₂)2SnCl(S₂CN(C₃H₇-n)2)] 
• 479200-15-2 (phenyl)3Sn(N,N-di-n-propyl dithiocarbamate) 
• 112614-53-6 bis(N,N-di(n-propyl)dithiocarbamato)dioxo(triphenylphosphine oxide)uranium(VI) 
• 14354-08-6 [Cu(S2CNPr2)2] 
• 138144-76-0 C₁₉H₂₄BrNS₂Te 

Relevant academic research and scientific papers

Structure of bis(dipropyldithiocarbamate) cadmium(II), [Cd2(n-Pr2dtc)4] (dtc = dithiocarbamate)

The cadmium complex of bis(dipropyldithiocarbamate), [Cd2(n-Pr2dtc)4] (dtc = dithiocarbamate) was crystallized from ethylether. It crystallizes in the monoclinic system, space group P21/c, with lattice parameters, a = 8.2532(1), b = 19.4519(1), c = 13.4163(2) A, β = 99.243(1)°, and Z = 4. The X-ray single-crystal structure of [Cd2(n-Pr2dtc)4] reveals that the complex is binuclear in the solid state and the Cd atom has a distorted square-pyramidal coordination environment and four equatorial donors are the two bidentate chelate sulfur atoms from two dtc ligands, of which the sulfur atom from the bridging dtc ligand occupies the apical position of the symmetry-related Cd atom in the dimer structure.

Binding of Gold(III) from Solutions by Tetranuclear Lead(II) Dipropyldithiocarbamate [Pb4{S2CN(C3H7)2}8] and Chemisorption Synthesis of the Double Ionic Polymer Complex ([Au{S2CN(C3H7)2}2][PbCl3] · 0.5CH3–C6H5) n: Heteronuclear (13 C, 15 N) CP-MAS NMR, Structural Organization, and Construction Principles of Cationic and Anionic Polymer Chains

Abstract: Solid-state 13C and 15N CP-MAS NMR data adequately reflected the presence of four nonequivalent PrDtc ligands in the tetranuclear lead(II) N,N-dipropyldithiocarbamate (PrDtc), [Pb4{S2CN(C3H7)2}8] (I); the spin–spin coupling constants 3J(15N–207Pb) for the ligands were estimated. It was shown by 13C MAS NMR that the chemisorption binding of AuCl3 from a solution in 2M HCl using lead(II) dipropyldithiocarbamate is accompanied by complete redistribution of the PrDtc ligands from Pb(II) to Au(III) coordination sphere; this gives the double complex of [Au{S2CN(C3H7)2}2][PbCl3] (II). Upon crystallization from an acetone–toluene mixture (3 : 1), this complex was isolated as the solvated form ([Au{S2CN(C3H7)2}2][PbCl3] ? 1/2CH3C6H5)n (IIa), which was characterized by X-ray diffraction (CIF file CCDC no. 1978947). The cationic part of the complex is represented by non-centrosymmetric gold(III) complex ions, [Au{S2CN(C3H7)2}2]+, which are combined by pairs of nonequivalent Au···S secondary bonds, thus forming supramolecular pseudo-polymer chain ([Au{S2CN(C3H7)2}2]+)n. The 1D polymeric trichloroplumbate(II) anion, {[Pb(μ2-Cl)3]–}n, acts as the counter-ion. The C–H···Cl hydrogen bonds between the anionic and cationic chains lead to formation of channels in the crystal lattice, which are occupied by solvating toluene molecules.

Principles of the Construction of Polymer Structures, Heteronuclear (13C, 15N) CP-MAS NMR, and Thermal Behavior of Heteroleptic Bismuth(III) Complexes of the General Composition [Bi(S2CNR2)2X] (X = NO3, Cl)

Abstract: The crystalline heteroleptic bismuth(III) complexes, [Bi{S2CN(iso-C4H9)2}2(NO3)] (I) and [Bi{S2CN(C3H7)2}2Cl] (II), are isolated in preparative yields. Both compounds form 1D polymer structures and are characterized by X-ray diffraction analysis (CIF files CCDC nos. 1877115 (I) and 1876364 (II)) and (13C, 15N) CP-MAS NMR spectroscopy. The coordination mode of each of the dialkyldithiocarbamate ligands is S,S′-anisobidentately terminal. The inorganic anions performing the μ2-bridging function participate in the binding of the adjacent metallic atoms to form zigzag polymer chains. A new mode of bismuth(III) binding involving all oxygen atoms (O,O'-anisobidentate coordination to each adjacent bismuth atom) is found for the bridging nitrate groups in compound I. The bismuth atoms in the studied compounds are characterized by the eightfold [BiS4O4] (I) or sixfold [BiS4Cl2] (II) environment. The thermal behavior of the synthesized complexes is characterized by the data of simultaneous thermal analysis, using parallel recording of thermogravimetry and differential scanning calorimetry curves. In both cases, Bi2S3 is the only final product of the thermal transformations of compounds I and II.

CARBONIC ANHYDRASE INHIBITOR COMPRISING A DITHIOCARBAMATE

A carbonic anhydrase inhibitor which comprises a compound of general formula: R 1RZN-CSz-M+ for use in the treatment of microbial infection, eye disease or cancer; wherein R1 and R2 are each independently selected from H or an organic substituent, or together form a ring, and optionally contain one or more heteroatoms; wherein R and R2 together comprise at least 5 carbon atoms or at least 2 carbon atoms and a heteroatom, or R2 comprises at least 4 carbon atoms; and wherein M+ comprises a monovalent cation

Dithiocarbamates: A new class of carbonic anhydrase inhibitors. Crystallographic and kinetic investigations

The zinc enzyme carbonic anhydrase (CA, EC 4.2.1.1) is inhibited by several classes of zinc-binders (sulfonamides, sulfamates, and sulfamides) as well as by compounds which do not interact with the metal ion (phenols, polyamines and coumarins). Here we report a new class of potent CA inhibitors which bind the zinc ion: the dithiocarbamates (DTCs). They coordinate to the zinc ion from the enzyme active site in monodentate manner and establish many favorable interactions with amino acid residues nearby. Several low nanomolar CA I, II and IX inhibitors were detected.

Dithiocarbamates strongly inhibit carbonic anhydrases and show antiglaucoma action in vivo

A series of dithiocarbamates were prepared by reaction of primary/secondary amines with carbon disulfide in the presence of bases. These compounds were tested for the inhibition of four human (h) isoforms of the zinc enzyme carbonic anhydrase, CA (EC 4.2.1.1), hCA I, II, IX, and XII, involved in pathologies such as glaucoma (CA II and XII) or cancer (CA IX). Several low nanomolar inhibitors targeting these CAs were detected. The X-ray crystal structure of the hCA II adduct with morpholine dithiocarbamate evidenced the inhibition mechanism of these compounds, which coordinate to the metal ion through a sulfur atom from the dithiocarbamate zinc-binding function. Some dithiocarbamates showed an effective intraocular pressure lowering activity in an animal model of glucoma.

Preparation and characterization of a series of bromodiphenyl(N,N-dialkyldithiocarbamato)tellurium(IV) compounds where R = Me, Et, i-Pr, Bu, and of chlorodiphenyl(N,N-dibutyldithiocarbamato)telluriumm(IV) and diphenylbis(N,N-dibutyldithiocarbamato)tellurium(IV). Crystal structure of P...

The series Ph2TeBr, where R = Bu, Pr, i-Pr, Et, and Me, as well as Ph2TeCl and Ph2Te2, where R = Bu, Pr, have been synthesized and characterized by elemental analysis and vibrational spectroscopy.Comparisons of the effect of changing R groups and halogen atoms can be made based on the two crystal structures determined herein along with earlier work.The geometry about tellurium is consistent with that of a distorted sawhorse structure where the dithiocarbamate groups are monodentate (or anisobidentate).The crystal structures of Ph2TeBr, 4, and Ph2Te2, 7, were completed.The cell parameters for 4 are a = 11.204(3) Angstroem, b = 14.106(11) Angstroem, c = 13.867(10) Angstroem, α = 99.62(6) deg, β = 102.76(5) deg, γ = 87.73(4) deg, V = 2107 Angstroem3, Z = 4, R = 0.0448, and Rw = 0.0489 and for 7 are a = 19.392(6) Angstroem, b = 9.622(2) Angstroem, c = 19.089(6) Angstroem, β = 104.70(2) deg, V = 3445(2) Angstroem3, Z = 4, R = 0.0397, and Rw = 0.0439.Nuclear magnetic resonance spectra are not simple and indicate that several species are present in solution, as rearrangements and reductive elimination take place. Key words: structure, tellurium, bromo, diphenyl, dialkyldithiocarbamato.

Method of preparation of dithiocarbamate complexes of molybdenum (VI)

An improved process for preparing dihydrocarbyl substituted dithiocarbamates of molybdenum (VI) wherein an alkali metal ammonium or substituted ammonium salt of a dihydrocarbyl substituted dithiocarbamate is reacted with an alkali metal molybdate in the presence of an organic acid. The process is carried out in an inert atmosphere and within a relatively narrow range of temperatures. The dihydrocarbyl substituted dithiocarbamate of molybdenum (VI) may be recrystallized after preparation to increase its purity. The dihydrocarbyl substituted dithiocarbamate of molybdenum (VI) is produced at a temperature within the range from about -10° C. to about +25° C. at a pH during neutralization within the range from about 5.0 to about 8.0.

Reactions of Hydrazidoyl Chlorides with Sodium N,N-Dialkyldithiocarbamates

The reaction of N-arylbenzhydrazidoyl chlorides (1) with sodium N,N-dialkyldithiocarbamates yields the hydrazone derivatives 2, which react further to form 4 unless the reaction sites are sterically crowded.