41443-37-2

Usage

Structure

Five-membered aromatic ring with two nitrogen atoms at positions 1 and 2, an amino group at position 3, and two phenyl groups attached to nitrogen atoms at positions 1 and 5.

Type

Derivative of pyrazole

Potential applications

Medicinal chemistry and pharmaceutical research due to possible biological activity and interactions with biological systems.

Additional research needed

Further studies are required to explore the compound's potential uses and properties.

Upstream product

• 14901-33-8 Phenylpropiolsaeurethioanilid 
• 302-01-2 hydrazine 
• 1185994-04-0 5⁽³⁾-(2-bromoanilino)-3⁽⁵⁾-phenyl-1H-pyrazole 
• 98-86-2 acetophenone 
• 16516-19-1 O-ethyl 3-oxo-3-phenylpropanethioate 
• 104-15-4 toluene-4-sulfonic acid 
• 1576-35-8 toluene-4-sulfonic acid hydrazide 
• 92133-94-3 3-phenyl-1-(4-toluenesulfonyl)pyrazol-5-amine 
• 108-86-1 bromobenzene 
• 103-72-0 phenyl isothiocyanate 
• 1004-22-4 (phenylethynyl)sodium 
• 81016-31-1 3-anilino-3-methylthio-1-phenylprop-2-en-1-one 

Downstream Products

• 119541-27-4 1,7-diphenyl-3-benzyl-1,2,3,4-tetrahydropyrazolo<1,5-a>triazine 
• 119541-29-6 3-Methyl-1,7-diphenyl-1,2,3,4-tetrahydro-pyrazolo[1,5-a][1,3,5]triazine 
• 119541-28-5 3-Ethyl-1,7-diphenyl-1,2,3,4-tetrahydro-pyrazolo[1,5-a][1,3,5]triazine 
• 119541-30-9 3-(4-Methoxy-phenyl)-1,7-diphenyl-1,2,3,4-tetrahydro-pyrazolo[1,5-a][1,3,5]triazine 

Relevant academic research and scientific papers

Pd-Catalyzed N-Arylations of 3-Aryl-1-tosyl-1H-pyrazol-5-amines with Arylbromides and the Migration of Ts Group

An efficient palladium-catalyzed N-arylations of 3-aryl-1-tosyl-1H-pyrazol-5-amines with arylbromides is established. A series of diversified N-arylated products are obtained in excellent yields with broad substrate scope. Importantly, the N-arylated products undergo 1,4- and 1,6-migration reactions of Ts group under the action of Cs2CO3, affording the N-Ts-substituted pyrroles as major products (1,6-migration). Similar results can also be directly obtained by palladium-catalyzed reactions of 3-aryl-1-tosyl-1H-pyrazol-5-amines with arylbromides in the presence of Cs2CO3 as a base. Mechanistic studies reveal that the Ts-migration is achieved through an intermolecular pathway.

Tetrabutylammonium Iodide Mediated Sulfenylation of Poly-substituted 1 H -Pyrazol-5-amines with Arylsulfonyl Hydrazides

A TBAI-mediated sulfenylation of N,3-diaryl-1-arylsulfonyl-1H-pyrazol-5-amines with arylsulfonyl hydrazides has been established, and an expanded inventory of N,5-diaryl-4-(arylthio)-1H-pyrazol-3-amines was constructed through C-S bond formation and N-S bond breaking. Mechanistic investigations suggest thiosulfonate as a key intermediate in the sulfenylation, and the detosylation is promoted by the generated arylsulfinic acid. The method is characterized by simple operating conditions, broad substrate range as well as gramscale reaction.

Efficient routes to pyrazolo[3,4-b]indoles and pyrazolo[1,5-a] benzimidazoles via palladium- and copper-catalyzed intramolecular C-C and C-N bond formation

(Chemical Equation Presented) Efficient synthetic routes to pyrazolo[3,4-b]indoles and pyrazolo[1,5-a]benzimidazoles via intramolecular palladium- and copper-catalyzed cyclization of 1-aryl/1-unsubstituted 5-(2-bromoanilino)-pyrazole precursors via intram

Synthesis of amino substituted pyrazoles

An efficient and convenient synthesis of substituted pyrazoles with aryl and heteroarylamino substituents attached to the C-3 and C-5 positions by the action of hydrazine hydrate on either ketene N,S-acetals or mixed N,N-aminals hydrate is reported.

Synthesis of aminopyrazoles from α- oxoketene O,N-acetals using Montmorillonite K-10/Ultrasound

5(3)-Amino-3(5) phenylpyrazoles 3a-f have been conveniently prepared by condensation of α-oxoketene O,N-acetals 2a-g with hydrazine using montmorillonite K-10 as solid support under sonication.

Reaction of Polarized Keten S,N-Acetals with Hydrazine: A Facile General Route to 3(5)-Substitutedamino-4,5(3)-substitutedpyrazoles

A convenient general route for 3(5)-aryl-5(3)-N-aryl/alkyl/benzyl/amino-1(H)-pyrazoles (2a-r) and 3(5)-amino-5(3)-arylamino-4-cyano/aryl-pyrazoles (5a-c) has been developed involving the reaction of respective polarized keten S,N-acetals with hydrazine hy