41447-18-1

Usage

Uses

Used in Pharmaceutical Industry:
(S)-1-Methylpiperidine-2-carboxylic acid is used as a key intermediate in the synthesis of pharmaceuticals for its potential role in the development of new drugs and medicinal compounds.
Used in Medicinal Chemistry Research:
(S)-1-Methylpiperidine-2-carboxylic acid serves as a valuable research tool in medicinal chemistry, aiding in the exploration of its properties and applications, which are currently a subject of ongoing studies.
Used in Asymmetric Synthesis:
(S)-1-Methylpiperidine-2-carboxylic acid is utilized as a chiral building block in asymmetric synthesis, contributing to the creation of enantiomerically pure molecules, which are crucial for the efficacy and safety of many drugs.
Used in Drug Discovery:
As a compound of interest in the field of organic chemistry, (S)-1-Methylpiperidine-2-carboxylic acid is employed in drug discovery processes to identify and develop novel therapeutic agents.

Upstream product

• 30727-18-5 ethyl 1-methylpiperidine-2-carboxylate 
• 626-67-5 N-methylcyclohexylamine 
• 124-38-9 carbon dioxide 

Downstream Products

• 101353-77-9 1-methyl-piperidine-2-carboxylic acid-(N-ethyl-anilide) 
• 110154-90-0 1-methyl-piperidine-2-carboxylic acid-(4-butoxy-2-methyl-anilide) 
• 113061-48-6 1-methyl-piperidine-2-carboxylic acid-(4-butoxy-2,6-dimethyl-anilide) 
• 108239-53-8 1-methyl-piperidine-2-carboxylic acid benzylamide 
• 20845-34-5 (1-methyl-piperidin-2-yl)-methanol 
• 945423-49-4 1-methyl-piperidine-2-carboxylic acid (2'-methyl-5'-oxazol-2-yl-biphenyl-4-yl)-amide 
• 1123512-46-8 N-(5-(5-(4-(difluoromethoxy)phenyl)pyrimidin-2-ylamino)-2-methylphenyl)-1-methylpiperidine-2-carboxamide 
• 58754-48-6 encainide 
• 921928-02-1 (S)-1-Methyl-piperidine-2-carboxylic acid pentafluorophenyl ester 
• 1443240-33-2 1-(5-tert-butyl-2-p-tolyl-2H-pyrazol-3-yl)-3-{(1S,4R)-4-[3-((S)-1-methyl-piperidin-2-yl)-[1,2,4]triazolo[4,3-a]pyridin-6-yloxy]-1,2,3,4-tetrahydro-naphthalen-1-yl}-urea 

Relevant academic research and scientific papers

Photolysis of Tertiary Amines in the Presence of CO2: The Paths to Formic Acid, α-Amino Acids, and 1,2-Diamines

The photolysis of triethylamine (1a) in the presence of carbon dioxide leads to the hydrogenation of CO2, the α-C-C coupling of 1a, and the CO2 insertion into the α-C-H σ-bond of amine 1a. This reaction is proposed to proceed through the radical ion pair [R3N?+·CO2?-] generated by the photoionization of amine 1a and the electron capture by CO2. The presence of lithium tetrafluoroborate in the reaction medium promotes the efficient and stereoselective α-C-C coupling of 1a by enhancing the production of α-dialkylamino radicals and the isomerization of N,N,N′,N′-tetraethylbutane-2,3-diamine (4a).

Mechanism of elimination of amino acid derivatives in the gas phase. Pyrolysis kinetics of ethyl picolinate, ethyl 1-methylpipecolinate and picolinic acid

The kinetics of the gas-phase elimination of the title compounds were determined in a static reaction system over the temperature range 180.8-419.4 °C and the pressure range 15-86 Torr (1 Torr = 133.3 Pa). The reactions are homogeneous and unimolecular and obey a first-order rate law. The observed rate coefficients are represented by the following Arrhenius equations: for ethyl picolinate, log[k1(s-1)] = (11.30 ± 0.24) -(180.9 ± 3.0) Kj mol-1 (2.303 RT)-1, for ethyl 1-methylpipecolinate, log[k1(s-1)] = (13.36 ± 0.31) -(209.5 ± 3.9) Kj mol-1 (2.303 RT)-1 and for picolinic acid, log[k1(s-1)] = (12.05 ± 0.10) -(135.7 ± 0.9) Kj mol-1 (2.303 RT)-1. The data from this work together with those reported in the literature confirm previous considerations that amino acids or α-nitrogen substituents of carboxylic acids undergo an extremely rapid decarboxylation process. The pyrolysis kinetics of picolinic acid, which is an intermediate of ethyl picolinate elimination, showed a dramatic fast decomposition into pyridine and CO2 gas. The decarboxylation process of α-amino or α-nitrogen substituents of carboxylic acids differs from the decarboxylation elimination of several known α-substituted carboxylic acids in the gas phase. Copyright