41465-66-1

Upstream product

• 47305-95-3 3-(4-Benzylpiperazino)propiophenone 
• 2520-08-3 1-benzyl-4(β-benzoylethyl) piperazine dihydrochloride 
• 5321-63-1 dihydrochloride salt of 1-benzylpiperazine 
• 98-86-2 acetophenone 

Downstream Products

• 149848-07-7 γ-(4-benzyl piperazin-1-yl)-α-phenyl propanol benzoate 
• 149848-05-5 Acetic acid 3-(4-benzyl-piperazin-1-yl)-1-phenyl-propyl ester 

Relevant academic research and scientific papers

Synthesis of some unsymmetrical ester derivatives of γ-(4-Substituted piperazin-1-yl)-α-phenyl propanols with antispasmodic activity

Six new ester derivatives of γ-(4-substituted piperazinyl)-α-phenyl propanol were prepared by esterification of the γ-piperazinyl propanols. The derivatives were methyl, ethyl, phenyl and benzyl esters, and they were obtained in good yields using a solid-

1-PIPERAZINES AND SOME RELATED COMPOUNDS

Amino alcohols VIIIa-c, prepared by reduction of the Mannich bases VIa-c, were transformed by treatment with thionyl chloride to the chloro derivatives IXa-c which were subjected to substituttion reactions with the sodium salts of guaiacol, 2-ethoxyphenol and 2-benzyloxyphenol giving the title compounds IIIb,c, IVb,c and Va-c.N,N-Dimethyl-3-(2-benzyloxyphenoxy)-3-phenylpropylamine (Va) was partially demethylated by treatment with ethyl chloroformate and by the following alkaline hydrolysis to the secondary amine XI.Amines III-V and XI in high doses exhibit centralexcitation but do not show antireserpine activity; they have several structurally less specific effects (hypotensive, local anaesthetic, spasmolytic).