41467-26-9

Usage

Uses

Used in Pharmaceutical Industry:
1-(4-CHLORO-PHENYL)-3,3-BIS-METHYLSULFANYL-PROPENONE is used as a building block for the synthesis of various pharmaceuticals due to its unique chemical structure and reactivity, contributing to the development of new drugs with potential therapeutic applications.
Used in Agrochemical Industry:
In the agrochemical industry, 1-(4-CHLORO-PHENYL)-3,3-BIS-METHYLSULFANYL-PROPENONE serves as an intermediate for the production of agrochemicals, such as pesticides and herbicides, leveraging its chemical properties to enhance the effectiveness of these products.
Used in Dye Manufacturing:
1-(4-CHLORO-PHENYL)-3,3-BIS-METHYLSULFANYL-PROPENONE is used as an intermediate in the manufacturing of dyes, where its chemical composition plays a crucial role in the development of new dye formulations with improved color properties and stability.
Used in Organic Chemistry Research:
As a compound with potential biological activities, 1-(4-CHLORO-PHENYL)-3,3-BIS-METHYLSULFANYL-PROPENONE is utilized in organic chemistry research for studying its interactions with various enzymes, aiming to discover new applications in the field of biochemistry and drug development.

Upstream product

• 50850-04-9 1-(4-chlorophenyl)-3,3-dimercapto-2-propen-1-one 
• 74-88-4 methyl iodide 
• 75-15-0 carbon disulfide 
• 99-91-2 para-chloroacetophenone 
• 77-78-1 dimethyl sulfate 
• 74-83-9 methyl bromide 

Downstream Products

• 50267-88-4 (Z)-3-(4-chloro-phenyl)-3-methylsulfanyl-dithioacrylic acid methyl ester 
• 76369-36-3 4-(4-Chloro-phenyl)-6-morpholin-4-yl-pyrimidin-2-ylamine 
• 123559-07-9 2-(4-Chloro-phenyl)-4,4-bis-methylsulfanyl-but-3-en-2-ol 
• 90254-55-0 7-(p-chlorophenyl)-1,3-dimethyl-5-methylthiopyrido<2,3-d>pyrimidine-2,4(1H,3H)-dione 
• 130001-05-7 (E)-2-<(4-chlorpbenzoyl)methylene>-5,5-dimethyl-tetrahydro-2H-1,3-oxazine 
• 74-93-1 methylthiol 
• 126232-72-2 (R)-(-)-(E)-2-<(4-chlorobenzoyl)methylene>-4-ethyl-2-oxazolidine 
• 82754-46-9 E-3-Methylthio-1-(4-chlorophenyl)-2-propen-1-one 
• 140611-71-8 2-Acetoxy-3,3-bis(methylthio)-1-(4-chlorophenyl)-2-propen-1-one 
• 140611-76-3 1,6-Di(4-chlorophenyl)-3,3,4,4-tetra(methylthio)hexane-1,2,5,6-tetraone 
• 98606-78-1 2-bromo-1-(4-chlorophenyl)-3,3-bis(methylthio)prop-2-en-1-one 
• 120803-16-9 5-(4-chlorophenyl)-3-(methylthio)isoxazole 
• 120803-07-8 3-(4-chlorophenyl)-5-methylthio-isoxazole 
• 116991-69-6 (4-Chloro-phenyl)-(5-methylsulfanyl-1H-[1,2,3]triazol-4-yl)-methanone 

Relevant academic research and scientific papers

Transition metal free synthesis of multifunctional thiomethylated-benzenes from aryl/heteroaryl/cyclopropyl methyl ketones

A base-promoted strategic synthesis of various functionalized thiomethylated-benzenes has been established from aryl/heteroaryl/cyclopropyl methyl ketone. We can directly access the thiomethylated-benzene nucleus embedded with diverse functional group by

COMPOUNDS FOR INHIBITING TNIK AND MEDICAL USES THEREOF

The present disclosure provides the compound having inhibitory property against TNIK having a specific chemical structure or its pharmaceutically acceptable salt. The present disclosure also provides a composition comprising the compound or its pharmaceutically acceptable salt. The present disclosure also provides a medical use of the compound, its salt or the composition comprising the compound or its pharmaceutically acceptable salt for treating or preventing cancer. The present disclosure also provides a method of treatment or prevention of cancer comprising administering the compound, its salt or the composition comprising the compound or its salt to a subject in need of such treatment or prevention.

Synthesis of Partially Reduced Imidazo[1,2- a ]pyridines through an Unprecedented Base-Mediated (4+2) Cyclization

A water-mediated regioselective synthesis of 6,7-diaryl-5-oxo-2,3,5,6-tetrahydroimidazo[1,2-a]pyridine-6-carbonitriles was performed by the reaction of 2-[1-cyano-2,2-bis(methylsulfanyl)vinyl]benzonitrile with 1-aryl-2-(imidazolidin-2-ylidene)ethanones un

Synthesis and molecular docking studies of novel 2-(2-amino-6-phenyl-4-pyrimidinylamino) ethanol derivatives: Using ring-opening reactions of cyclic ketene-N,O-acetal

A series of six novel 2-(2-amino-6-phenyl-4-pyrimidinylamino) ethanol derivatives have been synthesized starting from commercially available substituted acetophenones via Oxoketene Dithioacetals with high yields. Ketene dithioacetal store act with 2-amino

Synthesis of β-amino-α,β-unsaturated ketone derivatives via sequential rhodium-catalyzed sulfur ylide formation/rearrangement

In the presence of a Rh(II) catalyst and β-(methylthio)-α,β-unsaturated ketones, 1-sulfonyl-1,2,3-triazoles can be converted into functionalized β-amino-α,β-unsaturated ketones via formation of α-imino rhodium carbene/sulfur ylide and subsequent rearrangement. The products decompose to useful 2-methylthiopyrrole derivatives conveniently in high yield.

Bronsted acid catalyzed PhSe transfer versus radical aryl transfer: Linear codimerization of styrenes and internal olefins

Bronsted acid p-TsOH·H2O-catalyzed hydrovinylation of styrenes with internal olefins α-oxo ketene dithioacetals was efficiently achieved in the presence of N-phenylselenophthalimide (N-PSP), regioselectively affording Markovnikov phenylselenati

Synthesis and anti-HCV determinant motif identification in pyranone carboxamide scaffold

Hepatitis C Virus exhibits high genetic diversity. The current treatment for genotype-1 with ～80% sustained virologic responses is a combination of pegylated interferon, ribavirin and boceprevir/telaprevir/simeprevir which is associated with several side

Copper-catalyzed trifluoromethylation of internal olefinic C-H bonds: Efficient routes to trifluoromethylated tetrasubstituted olefins and N-heterocycles

The functionalization of internal olefins has been a challenging task in organic synthesis. Efficient CuII-catalyzed trifluoromethylation of internal olefins, that is, α-oxoketene dithioacetals, has been achieved by using Cu(OH)2 as a catalyst and TMSCF3 as a trifluoromethylating reagent. The push-pull effect from the polarized olefin substrates facilitates the internal olefinic C-H trifluoromethylation. Cyclic and acyclic dithioalkyl α-oxoketene acetals were used as the substrates and various substituents were tolerated. The internal olefinic C-H bond cleavage was not involved in the rate-determining step, and a mechanism that involves radicals is proposed based on a TEMPO-quenching experiment of the trifluoromethylation reaction. Further derivatization of the resultant CF 3 olefins led to multifunctionalized tetrasubstituted CF3 olefins and trifluoromethylated N-heterocycles.

Synthesis and anti-HCV activity of 4-hydroxyamino α-pyranone carboxamide analogues

High genetic variability in hepatitis C virus (HCV), emergence of drug resistant viruses and side effects demand the requirement for development of new scaffolds to show an alternate mechanism. Herein, we report discovery of new scaffold I based on 4-hydr

Base mediated synthesis of α-aminated aroyl/acetylnaphthalenes through [4+2] annulations

We have developed a base promoted simple, efficient and alternative approach for the synthesis of 4-amino-3-aroyl//heteroaroyl/acetyl-2-methylsulfanyl-naphthalene-1-carbonitriles by reaction of easily accessible 3,3-bis(methylthio)-1-aryl/heteroaryl/acety