41484-35-9

Basic information

• Product Name: 3,5-Bis(1,1-dimethylethyl)-4-hydroxybenzenepropanoic acid thiodi-2,1-ethanediyl ester
• Synonyms: THIODIETHYLENE BIS(3,5-DI-TERT-BUTYL-4-HYDROXYHYDROCINNAMATE);3,5-bis(1,1-dimethylethyl)-4-hydroxybenzenepropanoicacidthiodi-2,1-ethanedi;4-hydroxy-3,5-di-tert-butylphenylpropionicacidthioglycolate;benzenepropanoicacid,3,5-bis(1,1-dimethylethyl)-4-hydroxy-,thiodi-2,1-ethane;Benzenepropanoicacid,3,5-bis(1,1-dimethylethyl)-4-hydroxy-,thiodi-2,1-ethanediylester;diylester;fenozan30;Thiodiethyleneglycolbis(3,5-di-tert-butyl-4-hydroxyhydrocinnamate)
• CAS NO: 41484-35-9
• Molecular Formula: C₃₈H₅₈O₆S
• Molecular Weight: 642.93
• EINECS: 255-392-8
• Product Categories: Organics
• Mol File: 41484-35-9.mol

Chemical Properties

• Melting Point: 78 °C
• Boiling Point: 659.4 °C at 760 mmHg
• Flash Point: 352.6 °C
• Appearance: /
• Density: 1.072 g/cm³
• Refractive Index: 1.526
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility: DMSO (Slightly), Methanol (Slightly)
• PKA: 12.02±0.40(Predicted)
• CAS DataBase Reference: 3,5-Bis(1,1-dimethylethyl)-4-hydroxybenzenepropanoic acid thiodi-2,1-ethanediyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 3,5-Bis(1,1-dimethylethyl)-4-hydroxybenzenepropanoic acid thiodi-2,1-ethanediyl ester(41484-35-9)
• EPA Substance Registry System: 3,5-Bis(1,1-dimethylethyl)-4-hydroxybenzenepropanoic acid thiodi-2,1-ethanediyl ester(41484-35-9)

Safety Data

• RTECS: DA8342500
• Hazardous Substances Data: 41484-35-9(Hazardous Substances Data)

Usage

Chemical Properties

Antioxidant 1035 is a sulfur containing primary (phenolic) antioxidant and heat stabilizer, provides efficient processing stabilization and long-term thermal stability with excellent system compatibility, low color and low volatile.

Uses

Different sources of media describe the Uses of 41484-35-9 differently. You can refer to the following data:
1. Antioxidant 1035 is suitable for polyolefins, linear polyesters, PVC, polyamides, polyurethanes, elastomers, adhesives, most widely used for carbon black containing polymers such as PE and XLPE wire and cable resins, LDPE wire and cable, PVA, polypropylene, elastomer high impact polystyrene. It can be used with auxiliary antioxidant to exert synergistic effect, and the antioxidant performance is better.
2. Irganox 1035 is a useful compound in studying of antioxidant diffusion in polyethylene hot-water pipes.

Application

Carbon black containing wire and cable resins, LDPE wire and cable, XLPE wire and cable, PP, HIPS, ABS, PVA, Polyol/PUR, Elastomers, Hot melt adhesives

Flammability and Explosibility

Notclassified

Safety

Avoid dust formation and to the environment. Avoid dust formation and ignition sources.

InChI:InChI=1/C19H28O4S/c1-11(17(21)22)12-8-13(18(2,3)4)16(23-15(20)10-24)14(9-12)19(5,6)7/h8-9,11,24H,10H2,1-7H3,(H,21,22)

Synthetic route

2,2'-thiobis-ethanol (111-48-8) + methyl 3-(4-hydroxy-3,5-di-tert-butyl)phenylpropanoate (6386-38-5) → 2-[2-[3-(4-hydroxy-3,5-di-tert-butyl-phenyl)propanoyloxy]ethylsulfanyl]ethyl 3-(4-hydroxy-3,5-di-tert-butyl-phenyl)propanoate (41484-35-9)

Conditions	Yield
With alumina-supported potassium hydroxide at 120 - 160℃; for 0.5h; Catalytic behavior; Temperature; Inert atmosphere;	99.3%

di-tert-butyl dicarbonate (24424-99-5) + 2-[2-[3-(4-hydroxy-3,5-di-tert-butyl-phenyl)propanoyloxy]ethylsulfanyl]ethyl 3-(4-hydroxy-3,5-di-tert-butyl-phenyl)propanoate (41484-35-9) → C48H74O10S

Conditions	Yield
With dmap In acetonitrile at 55℃; for 2h;	94%

Upstream product

• 111-48-8 2,2'-thiobis-ethanol 
• 6386-38-5 methyl 3-(4-hydroxy-3,5-di-tert-butyl)phenylpropanoate 

Relevant articles and documents

Synthesis method of thiodiethylene bis [3-(3, 5-di-tert-butyl-4-hydroxyphenyl) propionate]

The invention relates to a synthesis method of thiodiethylene bis [3-(3, 5-di-tert-butyl-4-hydroxyphenyl) propionate]. The method comprises the following steps: enabling 2, 6-di-tert-butylphenol to react with acrylate, and continuing to react with 2-chloroethanol, so as to obtain an intermediate 3-(3, 5-di-tert-butyl-4-tetrahydroxyphenyl) propionic acid 2-chloroethyl ester; and reacting with sodium sulfide in the presence of quaternary ammonium salt to obtain a target product. The synthesis method disclosed by the invention has the advantages of simple process, high product yield and high purity, and is particularly suitable for being applied to industrial production.

Preparation method of thioether sterically hindered phenol antioxidant

The invention discloses a preparation method of a thioether sterically hindered phenol antioxidant, which comprises the following steps: a first stage: carrying out transesterification on 3-(3, 5-di-tert-butyl-4-hydroxyphenyl) methyl propionate and thiodiglycol under the action of a solid base catalyst; a second stage: removing by-product methanol under reduced pressure; and a third stage, alternately removing unreacted raw materials by nitrogen purging and pressure reduction, cooling, filtering, and collecting the solid base catalyst to obtain the target product. The synthesis process is simple, solvent crystallization purification, drying and other operations do not need to be conducted on a reaction mixture, and the product can be obtained through direct cooling; the production period is short, the later solvent waste liquid treatment is reduced, and the production cost is obviously reduced.

Organothioethyl alcohol segmers as antidegradant synergists

This invention is concerned with the stabilization of organic materials subject to oxidative degradation. The synergists of this invention possess organothioethyl alcohol segmers or moieties which enhance the antioxidative activity of phenolic and amine stabilizers. The invention is also concerned with compounds that contain an organothioethyl alcohol moiety and their use in oxidizable materials in combination with polymerizable and/or conventional antidegradants.

Polymerizable thioester synergists

There are disclosed polymerizable thioester synergists which have utility in enhancing the antioxidative activity of phenolic and amine stabilizers. The invention is also concerned with the thioesters themselves, their use in oxidizable organics, their combination with polymerizable and/or conventional antioxidants, and with polymers which contain these thioesters as physical admixtures or segmeric units of the polymer.

Compositions containing antimicorbial agents in combination with stabilizers

Composition of an antimicrobial agent and an antioxidant having improved antimicrobial activity compared to the antimicrobial agent alone. The preferred environment of the invention is a composition of a thermoplastic resin, an antioxidant, and an antimicrobial agent, the latter two being compatible with the resin. The resin composition can contain other usual additives, and can be melt processed at an elevated temperature to form articles such as films or fibers having improved antimicrobial activity. A method for improving the efficacy of an antimicrobial agent by combining it with an antioxidant is disclosed. A method for melt-processing a resin composition containing an antimicrobial material is also disclosed, wherein the resin composition includes an antioxidant. The inventors have thus discovered and solved the problem of oxidation of an antimicrobial composition, particularly a resin composition containing an antimicrobial agent, which arises when the composition is processed at elevated temperatures, as are typically encountered when forming a fiber or film of the composition.

Synergistic antioxidant mixtures

Compounds prepared by reacting maleic anhydride, maleic acid or their esters with thiols; which exhibit a synergistic effect when combined with a phenolic antioxidant in the stabilization of organic materials such as natural and synthetic polymers, rubbers, lubricants and oil, etc. are disclosed.

Synergistic antioxidant mixtures

Compounds of the formula: STR1 wherein R, R' and R2 are alkyl radicals having 1 to 20 carbon atoms, phenyl radicals which may be substituted by 1 or 2 alkyl groups having 1 to 8 carbon atoms, aralkyl radicals having 7 to 12 carbon atoms, or cycloalkyl radicals having 5 to 12 carbon atoms; and wherein R3 is hydrogen or an alkyl radical having from 1 to 4 carbon atoms. These compounds have utility as synergistic stabilizers with phenolic type antioxidants for the stabilization of organic materials such as natural and synthetic polymers, rubbers, lubricants and oils, etc.

Synergistic antioxidant mixtures

Compounds of the formula: STR1 wherein R is selected from (1) alkyl radicals having 6 to 20 carbon atoms; (2) phenyl radicals which may be substituted by 1 or 2 alkyl groups having 1 to 8 carbon atoms; or (3) aralkyl radicals having 7 to 12 carbon atoms; and wherein R1 is selected from (1) alkylene radicals having 2 to 6 carbon atoms; (2) cycloalkylene radicals having 5 to 12 carbon atoms; (3) alkylcycloalkylene radicals of the formula --R3 --R2 (R4)n, wherein R2 is a cycloalkylene radical having 5 to 12 carbon and R3 and R4 are alkylene radicals having 1 to 6 carbon atoms, and n equals 1 or 0; (4) or a group of the formula --R5 --YR6, wherein R5 and R6 are alkylene radicals having 2 to 6 carbon atoms and Y is oxygen, sulfur, or a 1,4-phenylene radical. These compounds have utility as synergistic stabilizers with phenolic type antioxidants in the stabilization of organic materials such as natural and synthetic polymers, rubbers, lubricants and oils, etc.