41485-62-5Relevant academic research and scientific papers
Use of dibutyl[14C]formamide as a formylating reagent in the Vilsmeier-Haack reaction and synthesis of a 14C-labeled novel phosphodiesterase-4 (PDE-4) inhibitor
Ho, Jonathan Z.,Elmore, Charles S.,Wallace, Michael A.,Yao, Dan,Braun, Matthew P.,Dean, Dennis C.,Melillo, David G.,Chen, Cheng-Yi
, p. 1040 - 1047 (2005)
A simple, high-yielding synthesis of dibutyl[14C]formamide ([14C]DBF; 1) from 14CO2 was developed (Scheme 1): reaction of LiBEt3H and 14CO2 followed by aqueous workup gave H14CO2H in high yield. Conversion of the [14C]formic acid to 1 was effected by a standard carbodiimide coupling procedure. The utility of 1 as an alternative to dimethyl[ 14C]formamide ([14C]DMF) in alkylation reactions and in the [14C]Vilsmeier-Haack reaction was demonstrated for several substrates (Table 2). A 14C-labeled phosphodiesterase-4 (PDE-4) inhibitor, [14C]-2, was synthesized by application of this technology (Scheme 2).
