414910-00-2

Usage

Chemical class

piperidinecarboxylic acids

Derivative

piperidine

Substituent

fluorine-substituted phenyl group

Usage

building block in the synthesis of pharmaceuticals and organic compounds

Property

lipophilic (due to phenylmethyl ester)

Application

drug delivery, pharmaceutical industry

Value

valuable tool in medicinal chemistry for drug development

Upstream product

• 126378-73-2 N-<(Benzyloxy)carbonyl>-2-phenyl-2,3-dihydro-4-pyridone 
• 452-63-1 2-Bromo-5-fluorotoluene 
• 501-53-1 benzyl chloroformate 
• 620-08-6 4-methoxypyridine 
• 414909-98-1 phenylmethyl 2-(4-fluoro-2-methylphenyl)-4-oxo-3,4-dihydro-1(2H)-pyridinecarboxylate 

Downstream Products

• 629953-64-6 1-benzyloxycarbonyl-2-(4-fluoro-2-methylphenyl)-4,4-dimethoxy-piperidine 
• 414910-03-5 (2R)-N-{(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethyl}-2-(4-fluoro-2-methylphenyl)-N-methyl-4-oxo-1-piperidinecarboxamide 
• 758683-83-9 C₂₈H₃₂F₇N₃O 
• 732982-99-9 C₂₈H₃₂F₇N₃O 
• 578711-16-7 C₂₅H₂₈F₇N₃O 
• 578711-36-1 C₂₇H₃₀F₇N₃O 
• 578711-38-3 C₂₇H₃₀F₇N₃O 
• 578711-32-7 C₂₈H₃₂F₇N₃O 
• 578711-34-9 C₂₈H₃₂F₇N₃O 
• 578711-12-3 C₂₇H₃₂F₇N₃O₂ 
• 578711-14-5 C₂₇H₃₂F₇N₃O₂ 
• 414910-14-8 (2R)-N-{[3,5-bis(trifluoromethyl)phenyl]methyl}-2-(4-fluoro-2-methylphenyl)-N-methyl-4-oxo-1-piperidinecarboxamide 
• 579475-69-7 2-(4-fluoro-2-methylphenyl)-4-piperidinone camphor-10-sulfonate 

Relevant academic research and scientific papers

Discovery and biological characterization of (2 R,4 S)-1′-Acetyl- N -{(1 R)-1-[3,5-bis(trifluoromethyl)phenyl]ethyl}-2-(4-fluoro-2-methylphenyl)- N -methyl-4,4′-bipiperidine-1-carboxamide as a new potent and selective neurokinin 1 (NK1) recepto

A large body of compelling preclinical evidence supports the clinical use of neurokinin (NK) receptor antagonists in a plethora of CNS and non-CNS therapeutic areas. The significant investment made in this area over the past 2 decades culminated with the

Development of a control strategy for a defluorinated analogue in the manufacturing process of casopitant mesylate

Casopitant mesylate was identified as part of the search for drugs with activity on the Central Nervous System (CNS) by GlaxoSmithKline. During late-phase development studies to develop the manufacturing process, a new impurity was found. This synthetic i

PIPERIDINE COMPOUND AND METHOD FOR PRODUCING SAME

The present invention relates to a novel piperidine compound represented by the formula [I]: wherein Ring A represents an optionally substituted benzene ring, Ring B represents an optionally substituted benzene ring, R1 represents an optionally

Chemical compounds

Formula (1) wherein R represents a halogen atom or a C1-4 alkyl group; R1 represents a C1-4 alkyl group; R2 represents hydrogen or a C1-4 alkyl group; R3 represents hydrogen, or a C1-4 alkyl group; R4 represents a trifluorometyl group; R5 represents hydrogen, a C1-4 alkyl group or C(0)R6; R6? represents C1-4 alkyl, C3-7 cycloalkyl, NH(C1-4 alkyl) or N(C1-4alkyl)2; m is zero or an integer from 1 to 3; n is an integer from 1 to 3 and pharmaceutically acceptable salts and solvates thereof; to processes for their preparation and their use in the treatment of conditions mediated bytachykinins.

NK1 ANTAGONIST

The invention is to a compound exhibiting neurokinin inhibitory properties, a pharmaceutical composition comprising same and a method of treatment for neurokinin-meditated conditions.Formula (I)

NOVEL PIPERIDINE COMPOUND

The present invention provides a novel piperidine compound of the formula [I]: wherein Ring A represents an optionally substituted benzene ring, Ring B represents an optionally substituted benzene ring, R1 represents an optionally substituted alkyl group, an optionally substituted hydroxyl group, etc., or a group of the formula: (a) wherein R11 and R12 are the same or different, and each represents hydrogen atom, a substituted carbonyl group, a substituted sulfonyl group, an optionally substituted alkyl group, etc., R2 represents hydrogen atom, etc., Z represents oxygen atom or a group represented by -N(R3)-, R3 represents hydrogen atom or an alkyl group, etc., R4 represents hydrogen atom or an alkyl group, etc.,or a pharmaceutically acceptable salt thereof.