579475-69-7

Upstream product

• 414909-99-2 2-(4-fluoro-2-methyl-phenyl)-piperidine-4-one 
• 76-26-6 camphor-10-sulfonic acid 
• 452-63-1 2-Bromo-5-fluorotoluene 
• 414910-00-2 2-(4-fluoro-2-methyl-phenyl)-4-oxo-piperidine-1-carboxylic acid benzyl ester 
• 414909-98-1 phenylmethyl 2-(4-fluoro-2-methylphenyl)-4-oxo-3,4-dihydro-1(2H)-pyridinecarboxylate 
• 620-08-6 4-methoxypyridine 

Downstream Products

• 414910-03-5 (2R)-N-{(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethyl}-2-(4-fluoro-2-methylphenyl)-N-methyl-4-oxo-1-piperidinecarboxamide 
• 578710-96-0 C₂₆H₃₀F₇N₃O 
• 578710-94-8 C₂₆H₃₀F₇N₃O 
• 1265854-91-8 C₂₆H₂₈F₇N₃O 
• 1265855-31-9 C₂₇H₃₀F₇N₃O 
• 1265855-27-3 C₂₇H₃₀F₇N₃O 
• 692257-60-6 C₂₇H₃₀F₇N₃O 
• 740081-53-2 C₂₇H₃₀F₇N₃O 
• 758683-83-9 C₂₈H₃₂F₇N₃O 
• 732982-99-9 C₂₈H₃₂F₇N₃O 
• 578711-16-7 C₂₅H₂₈F₇N₃O 
• 578711-36-1 C₂₇H₃₀F₇N₃O 
• 578711-38-3 C₂₇H₃₀F₇N₃O 
• 578711-32-7 C₂₈H₃₂F₇N₃O 

Relevant academic research and scientific papers

Discovery and biological characterization of (2 R,4 S)-1′-Acetyl- N -{(1 R)-1-[3,5-bis(trifluoromethyl)phenyl]ethyl}-2-(4-fluoro-2-methylphenyl)- N -methyl-4,4′-bipiperidine-1-carboxamide as a new potent and selective neurokinin 1 (NK1) recepto

A large body of compelling preclinical evidence supports the clinical use of neurokinin (NK) receptor antagonists in a plethora of CNS and non-CNS therapeutic areas. The significant investment made in this area over the past 2 decades culminated with the

Chemical compounds

Formula (1) wherein R represents a halogen atom or a C1-4 alkyl group; R1 represents a C1-4 alkyl group; R2 represents hydrogen or a C1-4 alkyl group; R3 represents hydrogen, or a C1-4 alkyl group; R4 represents a trifluorometyl group; R5 represents hydrogen, a C1-4 alkyl group or C(0)R6; R6? represents C1-4 alkyl, C3-7 cycloalkyl, NH(C1-4 alkyl) or N(C1-4alkyl)2; m is zero or an integer from 1 to 3; n is an integer from 1 to 3 and pharmaceutically acceptable salts and solvates thereof; to processes for their preparation and their use in the treatment of conditions mediated bytachykinins.