4151-04-6

Basic information

• Product Name: METHYL 2-METHYL-3-(PIPERIDIN-1-YL)PROPANOATE
• Synonyms: METHYL 2-METHYL-3-(PIPERIDIN-1-YL)PROPANOATE;methyl alpha-methylpiperidine-1-propionate;2-Methyl-3-piperidinopropanoic acid methyl ester;2-Methyl-3-piperidinopropionic acid methyl ester;α-Methyl-1-piperidinepropanoic acid methyl ester;α-Methyl-1-piperidinepropionic acid methyl ester;Einecs 223-976-1
• CAS NO: 4151-04-6
• Molecular Formula: C₁₀H₁₉NO₂
• Molecular Weight: 185.26
• EINECS: 223-976-1
• Mol File: 4151-04-6.mol
• Article Data: 16

Chemical Properties

• Boiling Point: 253.2°Cat760mmHg
• Flash Point: 91.9°C
• Appearance: /
• Density: 0.982g/cm³
• PKA: 8.59±0.10(Predicted)
• CAS DataBase Reference: METHYL 2-METHYL-3-(PIPERIDIN-1-YL)PROPANOATE(CAS DataBase Reference)
• NIST Chemistry Reference: METHYL 2-METHYL-3-(PIPERIDIN-1-YL)PROPANOATE(4151-04-6)
• EPA Substance Registry System: METHYL 2-METHYL-3-(PIPERIDIN-1-YL)PROPANOATE(4151-04-6)

Safety Data

• Hazardous Substances Data: 4151-04-6(Hazardous Substances Data)

Usage

General Description

Methyl 2-methyl-3-(piperidin-1-yl)propanoate is a chemical compound with the molecular formula C11H21NO2. It is a propanoate ester that is commonly used in the pharmaceutical industry as an intermediate in the synthesis of various drugs. METHYL 2-METHYL-3-(PIPERIDIN-1-YL)PROPANOATE is also known for its use as a solvent and as a precursor in organic synthesis. It is a clear, colorless liquid with a mild, fruity odor. Methyl 2-methyl-3-(piperidin-1-yl)propanoate may pose health hazards if inhaled, and appropriate safety precautions should be taken when handling this chemical.

Upstream product

• 110-89-4 piperidine 
• 80-62-6 methacrylic acid methyl ester 
• 20609-71-6 3-bromo-2-methyl-propionic acid methyl ester 

Downstream Products

• 132887-69-5 β-piperidino-isobutyric acid anilide 
• 102309-95-5 β-piperidino-isobutyric acid-(4-isopentyloxy-anilide) 
• 102019-74-9 β-piperidino-isobutyric acid-(4-butoxy-anilide) 
• 109400-86-4 β-piperidino-isobutyric acid p-toluidide 
• 599-06-4 perfluoro(N-n-propylpiperidine) 
• 359-71-7 perfluoro-(1-methylpiperidine) 
• 678-26-2 perfluoropentane 
• 564-11-4 perfluoro-(1-ethylpiperidine) 
• 3710-77-8 perfluoro(N-iso-propylpiperidine) 

Relevant articles and documents

Dolomite (CaMg(CO3)2) as a recyclable natural catalyst in Henry, Knoevenagel, and Michael reactions

Iranian dolomite (CaMg(CO3)2) which consists of double-layered carbonates with Ca2+ and Mg2+ ions was utilized as a heterogeneous base catalyst in the CC, CN, and CS bond forming reactions via the Henry, Knoevenagel, aza-Michael, and thia-Michael transformations under mild conditions in water. Iranian dolomite has been characterized by X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FT-IR), Brunauer Emmett Teller (BET) and XRF chemical analysis, while its basic strength was evaluated by following the Hammett indicators procedure. This water-insoluble natural catalyst demonstrated high activity and was reusable.

Aza-michael addition of amines to α,β-unsaturated compounds using molecular iodine as catalyst

Aza-Michael adducts are obtained in very good yields by the conjugate addition of aliphatic amines to α,β-unsaturated compounds using molecular iodine as catalyst in dichloromethane at room temperature. Aromatic amines were found to be reactive under reflux in toluene.

Microwave-assisted, rapid, solvent-free aza-michael reaction by perchloric acid impregnated on silica gel

Highly efficient solvent-free aza-Michael additions of a variety of amines to,-unsaturated carbonyl compounds under microwave-irradiation conditions catalyzed by perchloric acid impregnated on silica gel (HClO4/SiO2) is reported. The reactions are completed within 2-7min in a microwave oven to produce the corresponding adducts in excellent yields, and the catalyst can be recovered and reused.