41537-61-5

Upstream product

• 21139-32-2 ethyl 3-phenyl-5-chloroindole-2-carboxylate 
• 25445-57-2 5-chloro-1-cyanomethyl-3-phenyl-indole-2-carboxylic acid ethyl ester 

Downstream Products

• 63458-08-2 8-chloro-2-(3-dimethylamino-propyl)-10-phenyl-3,4-dihydro-2H-pyrazino[1,2-a]indol-1-one 

Relevant academic research and scientific papers

Synthesis of 10-phenyl-1,2,3,4-tetrahydropyrazinoindoles and ethyl 1-(2-aminoethyl)-3-phenylindole-2-carboxylates

Cyanomethylation of 3-phenylindole-2-carboxylates (1a-k) with chloracetonitrile in the presence of sodium hydride in DMF gives the corresponding ethyl 1-(2-cyanomethyl)-3-phenylindole-2-carboxylates (2a-k) wich on reductive cyclization with LAH afford dir

10-Aryl-1,2,3,4-tetrahydropyrazino(1,2-α)indole and derivatives thereof

Novel 10-aryl-1,2,3,4-tetrahydropyrazino(1,2-α)indole and derivatives and intermediates for their preparation are described, the products having anticonvulsant and central nervous system depressant activity.