25445-57-2

Upstream product

• 21139-32-2 ethyl 3-phenyl-5-chloroindole-2-carboxylate 
• 107-14-2 chloroacetonitrile 

Downstream Products

• 25445-58-3 8-chloro-10-phenyl-3,4-dihydro-2H-pyrazino[1,2-a]indol-1-one 
• 39626-24-9 8-chloro-10-phenyl-1,2,3,4-tetrahydro-pyrazino[1,2-a]indole 
• 41537-61-5 1-(2-amino-ethyl)-5-chloro-3-phenyl-indole-2-carboxylic acid ethyl ester 
• 138653-96-0 1-Carboxymethyl-5-chloro-3-phenyl-1H-indole-2-carboxylic acid 

Relevant academic research and scientific papers

Reversed Chemoselectivity in Titanium-induced Coupling Reactions: Syntheses of Salvadoricine and Diazepam

Titanium/graphite-promoted indole formation is favoured over inter- as well as intra-molecular McMurry coupling as evidenced by chemoselective syntheses of compounds 2 and 5-7.

Synthesis of 10-phenyl-1,2,3,4-tetrahydropyrazinoindoles and ethyl 1-(2-aminoethyl)-3-phenylindole-2-carboxylates

Cyanomethylation of 3-phenylindole-2-carboxylates (1a-k) with chloracetonitrile in the presence of sodium hydride in DMF gives the corresponding ethyl 1-(2-cyanomethyl)-3-phenylindole-2-carboxylates (2a-k) wich on reductive cyclization with LAH afford dir

10-Aryl-1,2,3,4-tetrahydropyrazino(1,2-α)indole and derivatives thereof

Novel 10-aryl-1,2,3,4-tetrahydropyrazino(1,2-α)indole and derivatives and intermediates for their preparation are described, the products having anticonvulsant and central nervous system depressant activity.