41547-94-8Relevant academic research and scientific papers
Synthesis of ring II/III fragment of Kanamycin: A new minimum structural motif for aminoglycoside recognition
Zárate, Sandra G.,Bastida, Agatha,Santana, Andrés G.,Revuelta, Julia
, (2019)
A novel protocol has been established to prepare the kanamycin ring II/III fragment, which has been validated as a minimum structural motif for the development of new aminoglycosides on the basis of its bactericidal activity even against resistant strains. Furthermore, its ability to act as a AAC-(6′) and APH-(3′) binder, and as a poor substrate for the ravenous ANT-(4′), makes it an excellent candidate for the design of inhibitors of these aminoglycoside modifying enzymes.
miRNA PROCESSING INHIBITOR EFFICACY ASSAYS AND SUBSTANCES
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, (2009/04/24)
The invention relates to assays for assessing miRNA maturation effector (preferably: inhibitor) efficacy, and to substances useful for influencing, particularly for inhibiting, maturation of miRNA. According to the invention there is provided assay of miR
Regioselective modification of amino groups in aminoglycosides based on cyclic carbamate formation
Chen, Guihui,Pan, Pan,Yao, Yun,Chen, Ying,Meng, Xiangbao,Li, Zhongjun
, p. 9078 - 9087 (2008/12/22)
Conditions for regioselective introduction of cyclic carbamate into per-N-Cbz neamine and per-N-Cbz kanamycin A have been found. The position and number of cyclic carbamate formed in these two aminoglycosides was controllable. On the base of selective cyclic carbamate formation, regioselective modification on N-1, N-6′ or both amino groups in neamine, and on N-6′, N-3″ or both amino groups in kanamycin A was achieved by ring-opening reaction with amines. A new neamine dimer linked at the N-1 was also synthesized with this method.
