Synthesis of ring II/III fragment of Kanamycin: A new minimum structural motif for aminoglycoside recognition

Article abstract of DOI:10.3390/antibiotics8030109

A novel protocol has been established to prepare the kanamycin ring II/III fragment, which has been validated as a minimum structural motif for the development of new aminoglycosides on the basis of its bactericidal activity even against resistant strains. Furthermore, its ability to act as a AAC-(6^′) and APH-(3^′) binder, and as a poor substrate for the ravenous ANT-(4^′), makes it an excellent candidate for the design of inhibitors of these aminoglycoside modifying enzymes.