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RDR 02308, also known as 2-(4-chlorophenyl)-N-(1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydropyrimidin-4-yl)acetamide, is a potent and selective inhibitor of the enzyme dihydroorotate dehydrogenase (DHODH). This enzyme plays a crucial role in the mitochondrial synthesis of pyrimidine, which is essential for DNA replication and cell proliferation. RDR 02308 has been studied for its potential therapeutic applications, particularly in the treatment of autoimmune diseases and certain types of cancer, due to its ability to modulate immune cell function and inhibit the proliferation of rapidly dividing cells. The compound's mechanism of action involves targeting DHODH, which is overexpressed in certain disease states, making it a promising candidate for targeted therapies.

4155-82-2

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4155-82-2 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 4155-82-2 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 4,1,5 and 5 respectively; the second part has 2 digits, 8 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 4155-82:
(6*4)+(5*1)+(4*5)+(3*5)+(2*8)+(1*2)=82
82 % 10 = 2
So 4155-82-2 is a valid CAS Registry Number.

4155-82-2Downstream Products

4155-82-2Relevant academic research and scientific papers

Synthesis of 1, 3, 5-trisubstituted-4,5-dihydro-1H-pyrazole catalyzed by vitamin B1 and its fluorescence properties

Zhang, Dawei,Ren, Lu,Liu, Ailing,Zhang, Yumin,Lv, Yang,Gu, Qiang

, p. 983 - 1001 (2022/02/09)

Abstract: An efficient synthesis of 1,3,5-trisubstituted-1H-pyrazoles was developed via cyclocondensation in 78–92% yields starting from α,β-unsaturated aldehydes/ketones with substituted phenylhydrazine using vitamin B1 as a catalyst, and was

Iron-catalyzed aerobic oxidative aromatization of 1,3,5-trisubstituted pyrazolines

Ananthnag, Guddekoppa S.,Adhikari, Adithya,Balakrishna, Maravanji S.

, p. 240 - 243 (2013/12/04)

A simple and high yielding method for the synthesis of tri-substituted pyrazoles via iron(III) catalyzed aerobic oxidative aromatization of pyrazolines has been reported. The process demonstrates a variety of functional group tolerance.

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