415678-23-8

Upstream product

• 7471-13-8 N-(pyrid-2-ylmethylene)-p-tolylamine 
• 1730-25-2 allylmagnesium bromide 
• 42910-72-5 (E)-4-methyl-N-(( pyridin-2-yl)methylene)aniline 
• 1121-60-4 pyridine-2-carbaldehyde 
• 24850-33-7 allyltributylstanane 
• 106-49-0 p-toluidine 

Relevant academic research and scientific papers

Synthesis, structure and catalytic properties of CNN pincer palladium(II) and ruthenium(II) complexes with N-substituted-2-aminomethyl-6-phenylpyridines

N-substituted-2-aminomethyl-6-phenylpyridines 2a-c have been easily prepared from commercially available 6-bromo-2-picolinaldehyde in two steps. Reaction of 2a-c with PdCl2 in toluene in the presence of triethylamine gave the CNN pincer Pd(ii) complexes 3a-c in 18-28% yields. The CNN pincer Ru(ii) complex 5 containing a Ru-NHR functionality could be obtained in a 71% yield by treatment of 2c with a Ru(ii) precursor instead of PdCl 2. Additionally, the related CNN pincer Ru(ii) complex 7 containing a Ru-NH2 functionality has been synthesized by the reaction of 2-aminomethyl-6-phenylpyridine with the same Ru(ii) precursor in a 68% yield. All the new compounds were characterized by elemental analysis (MS for ligands), 1H, 13C NMR, 31P{1H} NMR (for Ru complexes) and IR spectra. Molecular structures of Pd complex 3c as well as Ru complexes 5 and 7 have been determined by X-ray single-crystal diffraction. The obtained Pd complexes 3a-c were effective catalysts for the allylation of aldehydes as well as for three-component allylation of aldehydes, arylamines and allyltributyltin and their activity was found to be much higher than a related NCN Pd(ii) pincer in the allylation of aldehyde. On the other hand, the two new CNN pincer Ru(ii) complexes 5 and 7 displayed excellent catalytic activity in the transfer hydrogenation of ketones in refluxing 2-propanol with the latter being much more active. The final TOF values were up to 4510 h-1 with 0.01 mol% of 5 and 220800 h-1 with 0.005 mol% of 7, respectively. The Royal Society of Chemistry 2011.

In vitro antifungal activity of new series of homoallylamines and related compounds with inhibitory properties of the synthesis of fungal cell wall polymers

The synthesis, in vitro antifungal evaluation and SAR studies of 101 compounds of the 4-aryl-, 4-alkyl-, 4-pyridyl or -quinolinyl-4-N-arylamino-1-butenes series and related compounds, are reported here. Active structures showed to inhibit (1,3)-β-D-glucan and mainly chitin synthases, enzymes that catalyze the synthesis of the major fungal cell wall polymers.

4-N-aryl(benzyl)amino-4-hetaryl-1-butenes as building blocks in heterocyclic synthesis. 1. New route to 4,6-dimethyl-2-pyridylquinolines from the 4-N-p-methylphenylamino-4-pyridyl-1-butenes

Mediated-acid intramolecular cyclisation of 4-N-p-methylphenylamino-4-pyridyl-1-butenes 4-6 was used to obtain new C-2 pyridyl substituted 4,6-dimethyl-1,2,3,4-tetrahydroquinolines 7-9, which were oxidised then to their aromatic analogues 10-12 in good yi