415684-05-8

Basic information

• Product Name: Carbamic acid, [(2S)-3-chloro-2-hydroxypropyl]-, 1,1-dimethylethyl ester (9CI)
• Synonyms: Carbamic acid, [(2S)-3-chloro-2-hydroxypropyl]-, 1,1-dimethylethyl ester (9CI);CARBAMIC ACID, [(2S)-3-CHLORO-2-HYDROXYPROPYL]-, 1,1-DIMETHYLETHYL ESTER
• CAS NO: 415684-05-8
• Molecular Formula: C₈H₁₆ClNO₃
• Molecular Weight: 209.67054
• Product Categories: N-BOC
• Mol File: 415684-05-8.mol
• Article Data: 9

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Carbamic acid, [(2S)-3-chloro-2-hydroxypropyl]-, 1,1-dimethylethyl ester (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Carbamic acid, [(2S)-3-chloro-2-hydroxypropyl]-, 1,1-dimethylethyl ester (9CI)(415684-05-8)
• EPA Substance Registry System: Carbamic acid, [(2S)-3-chloro-2-hydroxypropyl]-, 1,1-dimethylethyl ester (9CI)(415684-05-8)

Safety Data

• Hazardous Substances Data: 415684-05-8(Hazardous Substances Data)

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 34839-13-9 (2S)-1-amino-3-chloropropan-2-ol hydrogen chloride 
• 681225-50-3 (2S)-1-azido-3-chloropropan-2-ol 
• 34839-13-9 (S)-1-amino-3-chloro-2-propanol hydrochloride 

Downstream Products

• 919357-47-4 tert-butyl {(5S)-3-[3,5-difluoro-4-(3-hydroxy-3-methylcyclobutyl)phenyl]-2-oxo-1,3-oxazolidin-5-yl}methylcarbamate 
• 919356-94-8 tert-butyl {(5S)-3-[3,5-difluoro-4-(3-methoxyazetidin-1-yl)phenyl]-2-oxo-1,3-oxazolidin-5-yl}methylcarbamate 
• 919357-35-0 C₂₀H₂₇F₂N₃O₅ 
• 919357-49-6 tert-butyl ((5S)-3-{3,5-difluoro-4-[3-hydroxy-3-(trifluoromethyl)azetidin-1-yl]phenyl}-2-oxo-1,3-oxazolidin-5-yl)methylcarbamate 
• 919356-96-0 tert-butyl {(5S)-3-[3,5-difluoro-4-(3-fluoroazetidin-1-yl)phenyl]-2-oxo-1,3-oxazolidin-5-yl}methylcarbamate 
• 919357-01-0 tert-butyl {(5S)-3-[3,5-difluoro-4-(3-{tert-butyldimethylsilyloxy}azetidin-1-yl)phenyl]-2-oxo-1,3-oxazolidin-5-yl}methylcarbamate 
• 919357-07-6 tert-butyl ((5S)-3-{3,5-difluoro-4-[3-(methoxyimino)azetidin-1-yl]phenyl}-2-oxo-1,3-oxazolidin-5-yl)methylcarbamate 
• 919357-28-1 tert-butyl {(5S)-3-[3,5-difluoro-4-(3-hydroxy-3-methylazetidin-1-yl)phenyl]-2-oxo-1,3-oxazolidin-5-yl}methylcarbamate 
• 919357-51-0 tert-butyl {(5S)-3-[-3,5-difluoro-4-(3-fluoro-3-methylazetidin-1-yl)phenyl]-2-oxo-1,3-oxazolidin-5-yl}methylcarbamate 
• 870447-57-7 tert-butyl (S)-N-[[3-[2,3,5-trifluoro-4-(thiomorpholin-4-yl)phenyl]-2-oxo-5-oxazolidinyl]methyl]carbamate 
• 870447-62-4 tert-butyl (S)-N-[[3-[2,3,5-trifluoro-4-[4-(benzyloxycarbonyl)piperazin-1-yl]phenyl]-2-oxo-5-oxazolidinyl]methyl]carbamate 

Relevant articles and documents

A fluorine-containing oxazolidinone compounds and its preparation method and application

The invention discloses a fluorine-containingoxazolidinonecompound as well as a preparation method and an application thereof. The structural formula of the fluorine-containingoxazolidinonecompound is as follows, wherein Rf refers to a trifluoromethyl group, a difluoromethyl group, a fluorine atom or perfluoralkane, R and Rindependently refer to H, C1-C6 straight-chain or branchedalkyl groups, C1-C6 straight-chain or branchedperfluoroalkyl groups, C1-C6 straight-chain or branchedalkoxygroups, a halogen such as F, Cl, Br or I, a nitro group, a cyano group or a phenyl group; R, R, R and Rindependently refer to H, F, Cl, Br, I or C1-C3 alkyl groups. The fluorine-containingoxazolidinonecompound has the better antimicrobial activity on watermelonanthracnose and cucumber grey mold and is particularly good in inhibitory activity on phytopathogencucumber grey mold of imperfect fungihyphomycetes, and a new choice is provided for development and utilization of new sterilization pesticides.

Synthesis and in vitro antibacterial activity of novel fluoroalkyl-substituted pyrazolyl oxazolidinones

A series of novel oxazolidinone derivatives bearing fluoroalkyl-substituted pyrazole as the C-ring structure were designed, synthesized and evaluated for their antibacterial activity against six Gram-positive bacterial pathogens. Most of the target compounds have good antibacterial activity. Especially, compounds 13f, 13i and 13l show excellent activity comparable to linezolid.

Stereoselective synthesis of novel (R)- and (S)-5-azidomethyl-2-oxazolidinones from (S)-epichlorohydrin: a key precursor for the oxazolidinone class of antibacterial agents

A facile synthesis of novel (R)- and (S)-5-azidomethyl-2-oxazolidinones starting from (S)-epichlorohydrin is described. The (R)-azide was utilized for the preparation of Linezolid.