41570-67-6Relevant articles and documents
Guanidine bases in synthesis: Extending the scope of the corey-chaykovsky epoxidation
Phillips, David J.,Graham, Andrew E.
, p. 769 - 773 (2010)
Guanidine bases, such as 1,5,7-triazabicyclo[4.4.0]dec-1-ene (TBD) or 7-methyl-1,5,7-triazabicyclo[4.4.0]dec-1-ene (MTBD), are highly effective reagents for the in situ generation of sulfonium ylides from sulfonium salts in Corey-Chaykovsky epoxidation reactions of aldehydes. These reactions proceed rapidly to produce the corresponding epoxides in excellent yields and with high selectivity for the trans product. Significantly, this reagent combination is applicable to both nonenolizable and enolizable aldehydes and α,β-unsaturated aldehydes.
A One-Pot Reaction toward the Diastereoselective Synthesis of Substituted Morpholines
Aubineau, Thomas,Cossy, Janine
supporting information, p. 7419 - 7423 (2018/12/11)
The diastereoselective synthesis of various substituted morpholines has been achieved from vinyloxiranes and amino-alcohols under sequential Pd(0)-catalyzed Tsuji-Trost/Fe(III)-catalyzed heterocyclization. Using the same strategy, 2,6-, 2,5-, and 2,3-disubstituted as well as 2,5,6- and 2,3,5-trisubstituted morpholines were obtained in good to excellent yields and diastereoselectivities.
Formal Asymmetric (4+1) Annulation Reaction between Sulfur Ylides and 1,3-Dienes
Rousseau, Olivier,Delaunay, Thierry,Dequirez, Geoffroy,Trieu-Van, Tran,Robeyns, Koen,Robiette, Rapha?l
supporting information, p. 12899 - 12902 (2015/09/07)
A highly enantioselective synthesis of functionalized cyclopentanoids by a formal asymmetric (4+1) annulation strategy was developed. The methodology consists of a stereoselective cyclopropanation reaction between chiral sulfur ylides and 1,3-dienes follo
