41580-72-7

Basic information

• Product Name: Benzene, 1-methoxy-3-(2-propynyloxy)-
• CAS NO: 41580-72-7
• Molecular Formula: C10H10O2
• Molecular Weight: 162.188
• Mol File: 41580-72-7.mol
• Article Data: 24

Chemical Properties

• CAS DataBase Reference: Benzene, 1-methoxy-3-(2-propynyloxy)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzene, 1-methoxy-3-(2-propynyloxy)-(41580-72-7)
• EPA Substance Registry System: Benzene, 1-methoxy-3-(2-propynyloxy)-(41580-72-7)

Safety Data

• Hazardous Substances Data: 41580-72-7(Hazardous Substances Data)

Upstream product

• 150-19-6 O-methylresorcine 
• 624-65-7 2-propynyl chloride 
• 107-19-7 propargyl alcohol 
• 106-96-7 propargyl bromide 
• 81447-09-8 1-bromo-3-<(3-methoxyphenyl)oxy>propene 

Downstream Products

• 1147710-90-4 3-methoxyphenyl 3-phenylselenylprop-2-yn-1-yl ether 
• 76322-24-2 7-methoxychroman-3-one 
• 109140-20-7 5-methoxy-3,4-dihydro-2H-1-benzopyran-3-one 
• 1286164-79-1 4-((3-methoxyphenoxy)methyl)-1-phenyl-1H-1,2,3-triazole 
• 1286164-78-0 1-benzyl-4-[(3-methoxyphenoxy)methyl]-1,2,3-triazole 
• 1262057-23-7 3-((3-methoxyphenoxy)methyl)cinnolin-4(1H)-one 
• 1262057-17-9 4-bromo-3-((3-methoxyphenoxy)methyl)cinnoline 
• 1262057-08-8 (E)-1-((2-(3-(3-methoxyphenoxy)prop-1-yn-1-yl)phenyl)diazenyl)piperidine 
• 3875-77-2 7-methoxychroman 

Relevant articles and documents

New ursolic acid derivatives bearing 1,2,3-triazole moieties: design, synthesis and anti-inflammatory activity in vitro and in vivo

Abstract: In order to discover novel anti-inflammatory agents, three series of compounds obtained by appending 1,2,3-triazole moieties on ursolic acid were designed and synthesized. All compounds have been screened for their anti-inflammatory activity by using an ear edema model. The potent anti-inflammatory compound was subjected to in vitro cyclooxygenase COX-1/COX-2 inhibition assays. In general, the derivatives were found to be potent anti-inflammatory activity. Especially, the compound 11b exhibited the strongest activity of all of the compounds prepared, with 82.81% inhibition after intraperitoneal administration, which was better than celecoxib as a positive control. Molecular docking results unclose the rationale for the interaction of the compound 11b with COX-2 enzyme. Further studies revealed that compound 11b exhibited effective COX-2 inhibitory activity, with half-maximal inhibitor concentration (IC50) value of 1.16?μM and selectivity index (SI = 64.66) value close to that of celecoxib (IC50 = 0.93?μM, SI = 65.47). Taken together, these results could suggest a promising chemotype for development of new COX-2-targeting anti-inflammatory agent. Graphic abstract: [Figure not available: see fulltext.]

Synthesis of pterocarpans through palladium-catalyzed oxyarylation of alkoxy-2H-chromenes with o-iodophenols

The oxyarylation of alkoxy-2H-chromenes (1a-e) with o-iodophenols substituted by electron-withdrawing (CHO) and electron-donating (OMe) groups is studied under two experimental conditions: a) Pd(OAc)2, Ag2CO3 in PEG-400 at 140 °C, 10 min and b) oxime-based palladacycle, DIPEA, in PEG-400 at 150 °C, 3–4 h. Pterocarpans are obtained in moderate to good chemical yields.

Electrostatic Control of Regioselectivity in Au(I)-Catalyzed Hydroarylation

Competing pathways in catalytic reactions often involve transition states with very different charge distributions, but this difference is rarely exploited to control selectivity. The proximity of a counterion to a charged catalyst in an ion paired comple