76322-24-2

Usage

Uses

Used in Pharmaceutical Development:
7-Methoxy-2H-chroMen-3(4H)-one is used as a potential pharmaceutical candidate for its anti-inflammatory, antioxidant, and anticancer properties. Its ability to inhibit certain enzymes and receptors in the body makes it a promising compound for the development of health-related products.
Used in Anticancer Applications:
7-Methoxy-2H-chroMen-3(4H)-one is used as an anticancer agent, targeting various types of cancer by modulating multiple signaling pathways and exhibiting inhibitory effects on tumor growth and progression.
Used in Drug Delivery Systems:
To enhance the efficacy and bioavailability of 7-Methoxy-2H-chroMen-3(4H)-one, novel drug delivery systems have been developed, employing various organic and metallic nanoparticles as carriers for its delivery, aiming to improve its therapeutic outcomes.

Upstream product

• 853925-13-0 3-acetoxy-7-methoxy-2H-chromene 
• 76322-19-5 ethyl(2-ethoxycarbonylmethoxy-4-methoxyphenyl)acetate 
• 673-22-3 2-Hydroxy-4-methoxybenzaldehyde 
• 57543-70-1 7-methoxybenzo-2H-pyran-3-carbonitrile 
• 76322-06-0 2-ethoxycarbonylmethoxy-4-methoxybenzaldehyde 
• 150-19-6 O-methylresorcine 
• 41580-72-7 m-methoxyphenyl 2-propynyl ether 
• 95-01-2 2,4-Dihydroxybenzaldehyde 
• 76322-11-7 (2-ethoxycarbonylmethoxy-4-methoxyphenyl)hydroxyacetonitrile 
• 115124-43-1 (2-carboxymethoxy-4-methoxy-phenyl)-acetic acid 
• 76322-29-7 ethyl 2-(2-hydroxy-4-methoxyphenyl)acetate 
• 20503-09-7 2-(2-hydroxy-4-methoxyphenyl)acetic acid 
• 552-41-0 1-(2-hydroxy-4-methoxyphenyl)ethanone 
• 89-84-9 2',4'-dihydroxy-4-acetophenone 

Relevant academic research and scientific papers

Rapid access to chroman-3-ones through gold-catalyzed oxidation of propargyl aryl ethers

The two-step: Chroman-3-ones are important intermediates for organic synthesis and medicinal chemistry. However, their syntheses require multiple steps and are not efficient. By using gold-catalyzed alkyne oxidation, this versatile heterocycle can be prepared in only two steps from readily available phenols and with mostly high efficiencies (see scheme).

ANTAGONISTS OF THE TRPV1 RECEPTOR AND USES THEREOF

The present application is directed to compounds that are TRPV1 antagonists and have formula (I) wherein variables Ar1, L1, R1, R2, R3, R4, R5, Y1, Y2, and Y3, are as defined in the description, which are useful for treating disorders caused by or exacerbated by vanilloid receptor activity.

ARYLSULFONYLMETHYL OR ARYLSULFONAMIDE SUBSTITUTED AROMATIC COMPOUNDS SUITABLE FOR TREATING DISORDERS THAT RESPOND TO MADULATION OF THE DOPAMINE D3 RECEPTOR

The present invention relates to aromatic compounds of the formula (I), wherein Ar is phenyl or an aromatic 5- or 6-membered C-bound heteroaromatic radical, wherein Ar may carry 1 radical Ra and wherein Ar may also carry 1 or 2 radicals Rb; X is N or CH; Y is O, S, -CH=N-, -CH=CH- or -N=CH-; A is CH2i O or S; E is CR6R7 or NR 3; R1 is C1-C4-alkyl, C3-C4-cycloalkyl, C3-C4-cycloalkylmethyl, C3-C4-alkenyl, fluorinated C1-C4--alkyl, fluorinated C3-C4-cycloalkyl, fluorinated C3-C4-cycloalkylmethyl, fluorinated C3-C4--alkenyl, formyl or C,-C3-alkylcarbonyl; R1a is H, C2-C4-alkyl, C3-C4-cycloalkyl, C3-C4-alkenyl, fluorinated C1-C4-alkyl, fluorinated C3-C4 -cycloalkyl, or R1a and R2 together are (CH2)n with n being 2 or 3, or R1a and R2a together are (CH2)n with n being 2 or 3; R2 and R2a are independently of each other H, CH3, CH2F, CHF2 or CF3; R3 is H or C1-C4-alkyl; R6, R7 independently of each other are selected from H, C1-C2-alkyl and fluorinated C1-C2-alkyl; and the physiologically tolerated acid addition salts thereof. The invention also relates to the use of a compound of the formula I or a pharmaceutically acceptable salt thereof for preparing a pharmaceutical composition for the treatment of a medical disorder susceptible to treatment with a dopamine D3 receptor ligand.