41590-65-2

Basic information

• Product Name: (2E)-3-phenyl-N-{3-[(4-{[(2E)-3-phenylprop-2-enoyl]amino}butyl)amino]propyl}prop-2-enamide
• CAS NO: 41590-65-2
• Molecular Formula: C₂₅H₃₁N₃O₂
• Molecular Weight: 405.5325
• Mol File: 41590-65-2.mol
• Article Data: 12

Chemical Properties

• Boiling Point: 702.4°C at 760 mmHg
• Flash Point: 217.9°C
• Density: 1.1g/cm³
• Vapor Pressure: 1.41E-19mmHg at 25°C
• Refractive Index: 1.596
• CAS DataBase Reference: (2E)-3-phenyl-N-{3-[(4-{[(2E)-3-phenylprop-2-enoyl]amino}butyl)amino]propyl}prop-2-enamide(CAS DataBase Reference)
• NIST Chemistry Reference: (2E)-3-phenyl-N-{3-[(4-{[(2E)-3-phenylprop-2-enoyl]amino}butyl)amino]propyl}prop-2-enamide(41590-65-2)
• EPA Substance Registry System: (2E)-3-phenyl-N-{3-[(4-{[(2E)-3-phenylprop-2-enoyl]amino}butyl)amino]propyl}prop-2-enamide(41590-65-2)

Safety Data

• Hazardous Substances Data: 41590-65-2(Hazardous Substances Data)

Upstream product

• 56-18-8 bis(3-aminopropyl)amine 
• 106727-87-1 C₂₁H₁₆N₂O₂ 
• 1885-38-7 cinnamic nitrile 
• 124-20-9 N-(3-aminopropyl)-1,4-diaminobutane 
• 140-10-3 (E)-3-phenylacrylic acid 
• 6047-90-1 (3E)-2-oxo-4-phenylbutenenitrile 
• 128459-10-9 N-Methoxydicinnamamide 
• 89332-58-1 3-trans cinnamoyl-2-oxazolone 
• 621-82-9 Cinnamic acid 
• 14618-10-1 5-Nitrobenz<1,6-d>-3H-1,2-oxathiole S,S-dioxide 
• 102-92-1 cinnamoyl chloride 
• 61912-03-6 2-hydroxy-4-phenyl-3-butenenitrile 
• 14371-10-9 (E)-3-phenylpropenal 
• 74058-65-4 N-thioxo-2 thiazolidine 

Relevant articles and documents

The synthesis of maytenine, N-methylspermidine and N-methylmaytenine

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Ruthenium-catalyzed oxidations for selective syntheses of ketones and acyl cyanides. Selective acylation of amino compounds with acyl cyanides

Oxidation of alcohols to the corresponding carbonyl compounds with tert-butyl hydroperoxide in the presence of dichlorotris(triphenylphosphine)ruthenium catalyst gives the corresponding carbonyl compounds with high efficiency. This method can be applied to the oxidation of cyanohydrins to give acyl cyanides which are versatile synthetic intermediates. Acylation of amino compounds with acyl cyanides thus obtained proceeds chemoselectively. Thus, the reaction of amino alcohols with acyl cynides gives N-acylated products exclusively. In the similar N-acylation of polyamines primary amines are selectively acylated in the presence of secondary amines. These reactions are highly useful for the synthesis of spermidine and spermine alkaloids such as spermidine alkaloids such as spermidine siderophores. Dimeric cyclocoupling reaction of diacyl cyanides such as iso- and terephthaloyl cyanides with polyamines can be performed under the similar reaction conditions to give the corresponding polyazamacrocycles with high efficiency.

Chemoselective Acylation of Primary Amines in the Presence of Secondary Amines with Acyl Cyanides. Highly Efficient Methods for the Synthesis of Spermidine and Spermine Alkaloid

Acyl cyanides are highly useful reagents for the chemoselective acylation of primary amines in the presence of secondary amines.The reaction provides the versatile method for the shortstep synthesis of various naturally occurring polyamines.