415917-91-8

Upstream product

• 3947-62-4 2,3,4,6-tetra-O-acetyl-α/β-D-galactopyranose 
• 7693-46-1 4-Nitrophenyl chloroformate 
• 4163-60-4 β-D-galactose peracetate 

Downstream Products

• 415917-96-3 4-nitrophenyl-[N,N'-(2,3,4,6-tetra-O-acetyl-α-D-galactopyranosyloxycarbonyl)-1,3-diaminopropyl]-carbonate 

Relevant academic research and scientific papers

New glycosidase activated nitric oxide donors: Glycose and 3-morphorlinosydnonimine conjugates

(Chemical Equation Presented) To achieve site specific delivery of nitric oxide (NO), a new class of glycosidase activated NO donors has been developed. Glucose, galactose, and N-acetylneuraminic acid were covalently coupled to 3-morphorlinosydnonimine (SIN-1), a mesoionic heterocyclic NO donor, via a carbamate linkage at the anomeric position. The β-glycosides were successfully prepared for these conjugates, while the α-glycosidic compounds were very unstable. The new stable sugar-NO conjugates could release NO in the presence of glycosidases. Such NO prodrugs may be used as enzyme activated NO donors in biomedical research.

Synthesis of new galactosyl and lactosyl carbamate-containing glycolipids

An efficient synthesis of mono-, di- and tetrasaccharides linked to a lipid has been developed. Galactose or lactose was covalently coupled to a glycyldioctadecylamide, via well-defined chemical steps, in both an α and β anomeric configuration. The multia