415918-01-3Relevant academic research and scientific papers
Synthesis and biological analysis of novel glycoside derivatives of L-AEP, as targeted antibacterial agents
Bovill, Richard,Evans, Philip G.,Howse, Gemma L.,Osborn, Helen M.I.
, p. 3774 - 3779 (2016)
To develop targeted methods for treating bacterial infections, the feasibility of using glycoside derivatives of the antibacterial compound L-R-aminoethylphosphonic acid (L-AEP) has been investigated. These derivatives are hypothesized to be taken up by b
New glycosidase activated nitric oxide donors: Glycose and 3-morphorlinosydnonimine conjugates
Cai, T. Bill,Lu, Dongning,Tang, Xiaoping,Zhang, Yalong,Landerholm, Megan,Wang, Peng George
, p. 3518 - 3524 (2007/10/03)
(Chemical Equation Presented) To achieve site specific delivery of nitric oxide (NO), a new class of glycosidase activated NO donors has been developed. Glucose, galactose, and N-acetylneuraminic acid were covalently coupled to 3-morphorlinosydnonimine (SIN-1), a mesoionic heterocyclic NO donor, via a carbamate linkage at the anomeric position. The β-glycosides were successfully prepared for these conjugates, while the α-glycosidic compounds were very unstable. The new stable sugar-NO conjugates could release NO in the presence of glycosidases. Such NO prodrugs may be used as enzyme activated NO donors in biomedical research.
Synthesis of new galactosyl and lactosyl carbamate-containing glycolipids
Azoulay, Michel,Escriou, Virginie,Florent, Jean-Claude,Monneret, Claude
, p. 841 - 853 (2007/10/03)
An efficient synthesis of mono-, di- and tetrasaccharides linked to a lipid has been developed. Galactose or lactose was covalently coupled to a glycyldioctadecylamide, via well-defined chemical steps, in both an α and β anomeric configuration. The multia
