415949-71-2

Upstream product

• 4358-87-6 (RS)-methyl mandelate 
• 107-30-2 chloromethyl methyl ether 
• 542-88-1 bis(2-chloromethyl)ether 
• 22446-37-3 methyl (2-hydroxyphenyl)acetate 
• 614-75-5 2-Hydroxyphenylacetic acid 

Relevant academic research and scientific papers

TRI-SUBSTITUTED ARYL AND HETEROARYL DERIVATIVES AS MODULATORS OF PI3-KINASE AND AUTOPHAGY PATHWAYS

The present disclosure relates to tri-substituted aryl and heteroaryl derivatives, pharmaceutical compositions containing them, and methods of using them, including methods for modulating autophagy or preventing, reversing, slowing or inhibiting the PI3K-AKT-MTOR pathway, and methods of treating diseases that are associated with autophagy or the PI3K-AKT-MTOR pathway.

PYRANOCHROMENYL PHENOL DERIVATIVE, AND PHARMACEUTICAL COMPOSITION FOR TREATING METABOLIC SYNDROME OR INFLAMMATORY DISEASE

Provided are a pyranochromenyl phenol derivative, a pharmaceutically acceptable salt thereof, or a solvate thereof. Also provided is a pharmaceutical composition for preventing or treating metabolic syndrome or inflammatory disease comprising same. The present invention is efficacious in preventing or treating metabolic syndrome or inflammatory disease and is chemically stable.

PYRANOCHROMENYLPHENOL DERIVATIVES AND PHARMACEUTICAL COMPOSITION FOR TREATING METABOLIC SYNDROME OR INFLAMMATORY DISEASE

Provided is a compound of the following Formula (I), a pharmaceutically acceptable salt thereof, or a solvate thereof. Further, provided is a pharmaceutical composition for preventing or treating a metabolic syndrome or an inflammatory disease, including the same. in the formula, R1 is a hydrogen atom, methyl, methoxy, or a halogen atom; R2 is a hydrogen atom; a substituted or unsubstituted straight or branched C1-C6 alkyl group; a halogen atom; a substituted or unsubstituted straight or branched C1-C6 alkoxy group; or a substituted or unsubstituted straight or branched C1-C4 thioalkyl group; R3 and R4 are each independently a hydrogen atom, or a C1-C2 alkyl group; and in the case of the substituted alkyl, the substituted alkoxy, and the substituted thioalkyl, the substituent is a straight or branched C1-C5 alkyl group, a halogen atom, a straight or branched C1-C5 alkoxy group, or a straight or branched C1-C3 thioalkyl group.

3-Propenyl derivatives of cephalosporin, compositions and their use

3-(3-hydroxyprop-1-(t)-enyl)-7β-(α-substituted acetamido)-ceph-3-em-4-carboxylic acids; 3-(3-carbamoyloxyprop-1-(t)-enyl)-7β-(α-substituted acetamido)-ceph-3-em-4-carboxylic acids; and 3-[3-(N-substituted carbamoyloxy)prop-1-(t)-enyl]-7β-(α-substituted acetamido)-ceph-3-em-4-carboxylic acids and derivatives and salts thereof and process for preparing such compounds. The compounds are useful as antibacterials and are active against a wide variety of gram positive and gram negative bacteria.