415967-68-9Relevant academic research and scientific papers
Practical Synthesis of Polysubstituted Haloimidazoles from 1,1-Dibromoalkenes and Amidines
Li, Yibiao,Cheng, Liang,Shao, Yan,Jiang, Shaohua,Cai, Jialing,Qing, Ning
, p. 4325 - 4329 (2015)
The copper-catalyzed cycloamination reaction of 1,1-dibromoalkenes with amidines affords a diverse set of polysubstituted haloimidazole derivatives. By using this strategy, high regio- and chemoselectivity has been achieved, using 4,7-diphenyl-1,10-phenanthroline as ligand without the addition of expensive catalysts to provide moderate to good yields. The copper-catalyzed cycloamination reaction of 1,1-dibromoalkenes with amidines affords a diverse set of polysubstituted haloimidazole derivatives. Moderate to good yields with high regio- and chemoselectivities were achieved by using 4,7-diphenyl-1,10-phenanthroline as ligand without the addition of expensive catalyst.
FORMYLATED XANTHOCILLIN ANALOGUES AS NEUROPROTECTIVE AGENTS
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Paragraph 0262; 0263; 0268; 0269, (2015/02/18)
Formylated xanthocillin analogs can be used in the treatment of neurodegenerative diseases. The analogs can be prepared synthetically, and at least some of the analogs can be obtained from a microorganism strain of the Penicillium chrysogenum species.
FORMYLATED XANTHOCILLIN ANALOGUES AS NEUROPROTECTANTS
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Paragraph 0150; 0151; 0156; 0157, (2015/01/18)
The present invention relates to formylated xanthocillin analogues for use in the treatment of neurodegenerative diseases, to some of said analogues, as well as to methods for obtaining them and pharmaceutical composition comprising them. The invention al
Efficient synthesis of the selective COX-2 inhibitor GW406381X
Whitehead, Andrew J.,Ward, Richard A.,Jones, Martin F.
, p. 911 - 913 (2008/02/04)
An efficient synthesis of the selective COX-2 inhibitor GW406381X is described via a novel intramolecular Mannich-type cyclisation to construct the pyrazolo-[1,5a]-pyridazine heterocyclic core.
Synthesis and Physical Properties of Asymmetric Diphenyldiacetylenic Liquid Crystals
Meng, H.-H. B.,Dalton, L. R.,Wu, S.-T.
, p. 303 - 314 (2007/10/02)
Fifty-six asymmetric diphenyl-diacetylene liquid crystal homologs including dialkyl, alkyl-alkoxy, cyano-alkyl, chloro-alkyl, fluoro-alkyl, difluoro-alkyl, lateral chloro-substituted fluoro-alkyl (or alkoxy), lateral fluoro-substituted asymmetric dialkyl, and vinyl-alkyl are synthesized and their physical properties evaluated.Among these asymmetric diphenyl-diacetylene liquid crystals, many dialkyl homologs exhibit low melting point, wide nematic range, and low heat of fusion.They are ideal host candidates for formulating eutectic mixtures.The polar groups make important contributions to the phase transition temperature, dielectric anisotropy, refractive indices and viscosity.Detailed effects depend on the position of the substitution.These new liquid-crystals compounds and mixtures are particularly useful for electro-optic modulation of infrared radiation. - Keywords: Diphenyl-diacetylenes, eutectic mixtures, electro-optic modulation, physical properties
