41621-84-5Relevant academic research and scientific papers
Catalysis of phosphorus(V)-mediated transformations: Dichlorination reactions of epoxides under appel conditions
Denton, Ross M.,Tang, Xiaoping,Przeslak, Adam
, p. 4678 - 4681 (2010)
A stereospecific triphenylphosphine oxide-catalyzed 1,2-dichlorination reaction of epoxides has been developed. The reaction is effective for a range of terminal and internal epoxides. In contrast to the classical Appel-type dichlorination of epoxides, oxalyl chloride is used as a stoichiometric reagent to generate the chlorophosphonium salt responsible for dichlorination from catalytic triphenylphosphine oxide.
