41652-38-4

Upstream product

• 643-65-2 3-methyl benzophenone 
• 21288-34-6 2-(3-benzoylphenyl)acetonitrile 
• 22071-24-5 3-benzoylbenzyl bromide 
• 22071-22-3 2-(3-benzoylphenyl)acetic acid 

Downstream Products

• 59512-30-0 2-(3-benzoyl-phenyl)-N-(4,5-dihydro-thiazol-2-yl)-acetamide 
• 60695-23-0 2-cyclohexylmethyl-1-[(3-benzoylphenyl)acetyl]piperidine 
• 60695-25-2 2,6-Dimethyl-1-{2-[3-(α-hydroxybenzyl)phenyl]ethyl}-piperidine 
• 60695-24-1 2-cyclohexylmethyl-1-{2-[3-(α-hydroxybenzyl)phenyl]ethyl}piperidine 
• 60695-26-3 N-<2-(3-benzoylphenyl)acetyl>-2,6-dimethylpiperidine 
• 60695-29-6 N-[(3-benzoylphenyl)acetyl]-N-(3-dimethylaminopropyl)amine 
• 81597-82-2 4-<2-(3-benzoylphenyl)-1-oxoethyl>morpholine 
• 60695-28-5 {3-[2-(3-Dimethylamino-propylamino)-ethyl]-phenyl}-phenyl-methanone; hydrochloride 
• 60695-27-4 4-[2-(3-benzoylphenyl)ethyl]morpholine hydrochloride 
• 81597-85-5 N-(3-Dimethylamino-propyl)-2-[3-(2-phenyl-[1,3]dioxolan-2-yl)-phenyl]-acetamide 
• 81597-83-3 3-<2-morpholino-2-oxoethyl>benzophenone cyclic ethylene acetal 
• 81597-86-6 N,N-Dimethyl-N'-{2-[3-(2-phenyl-[1,3]dioxolan-2-yl)-phenyl]-ethyl}-propane-1,3-diamine 
• 60695-78-5 {3-[2-(2-Cyclohexylmethyl-piperidin-1-yl)-ethyl]-phenyl}-phenyl-methanone 
• 167777-23-3 5α-cholestan-7α-yl (3-benzoylphenyl)acetate 

Relevant academic research and scientific papers

Photoinduced Molecular Transformations. Part 153. Long-Range Intramolecular Hydroxylation of C(25) of the Cholestane Side Chain

Alkoxyl radicals generated by photolysis of the hypoiodites of 5α-cholestan-7α-yl 4-(α-hydroxyphenylmethyl)phenylacetate and 5α-cholestan-7α-yl 3-propanoate, respectively, abstracted hydrogen from C(25) of their cholestane

Bulky amine analogues of ketoprofen: Potent antiinflammatory agents

Replacement of the carboxyl group of 2-(3-benzoylphenyl)propionic acid (Ketoprofen) with various bulky amines has produced a series of highly active antiinflammatory agents that have reduced intestinal ulcerogenicity and have better therapeutic ratios in the 21-day adjuvant arthritis assay on rats than currently marketed nonsteroidal antiinflammatory drugs. Activity is maintained on reduction of these 2-(3-benzoylphenyl)propyl bulky amines to the corresponding alcohols or methylene analogues, on conversion of the ketone function to a primary amine or oxime, and on introduction of a 4-halo substituent (Cl or F) on the terminal aromatic ring. Removal of the α-CH3 group greatly reduces the antiinflammatory activity of the series. These compounds have been synthesized by the reductive amination of 2-(3-bromophenyl)propionaldehyde with the respective amine followed by lithiation of this product and condensation with the appropriate benzonitrile.

4-(M-benzoylphenyl)butyric acid derivatives

Novel butyric acid derivatives of the formula SPC1 Wherein X, X1, X2 and X3 are individually selected from the group consisting of hydrogen, halogen, lower alkyl of 1 to 5 carbon atoms, lower alkoxy of 1 to 5 carbon atoms, lower alkylthio of 1 to 5 carbon atoms, trifluoromethoxy, trifluoromethylthio, trifluoromethyl, OH and dilower alkylamino of 1 to 5 carbon atoms for each alkyl, R is selected from the group consisting of hydrogen, lower alkyl of 1 to 5 carbon atoms, o-carboxyphenyl, 2,3-dihydroxypropyl and -CH2 -CH - CH2 EQU1 wherein P and Q are individually lower alkyl of 1 to 5 carbon atoms, Z and X4 are individually selected from the group consisting of hydrogen and lower alkyl of 1 to 5 carbon atoms and Y is selected from the group consisting of hydrogen and --OH and the dotted line indicates the optional presence of a double bond when Y is hydrogen and when R is hydrogen or o-carboxyphenyl, the salts thereof with a non-toxic pharmaceutically acceptable mineral or organic base, which compounds have anti-inflammatory and analgesic activity and are substantially devoid of ulcerigenic activity and their preparation and novel intermediates formed therein.