22071-22-3

Basic information

• Product Name: 3-BENZOYLPHENYLACETIC ACID
• Synonyms: (m-benzoylphenyl)-aceticaci;19421r.p.;2-(3-benzoylphenyl)aceticacid;3-benzoyl-benzeneaceticaci;3-benzoylbenzeneaceticacid;m-benzoylphenylaceticacid;3-BENZOYLPHENYLACETIC ACID;Desmethyl Ketoprofen
• CAS NO: 22071-22-3
• Molecular Formula: C₁₅H₁₂O₃
• Molecular Weight: 240.25
• EINECS: 244-760-3
• Product Categories: Aromatics;Intermediates & Fine Chemicals;Pharmaceuticals
• Mol File: 22071-22-3.mol
• Article Data: 8

Chemical Properties

• Melting Point: 111°C
• Boiling Point: 438.5°Cat760mmHg
• Flash Point: 233.1°C
• Appearance: /
• Density: 1.232g/cm³
• Vapor Pressure: 1.83E-08mmHg at 25°C
• Refractive Index: 1.605
• Storage Temp.: Refrigerator
• Solubility: Chloroform (Slightly), DMSO (Sparingly), Methanol (Slightly)
• PKA: 4.18±0.10(Predicted)
• CAS DataBase Reference: 3-BENZOYLPHENYLACETIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 3-BENZOYLPHENYLACETIC ACID(22071-22-3)
• EPA Substance Registry System: 3-BENZOYLPHENYLACETIC ACID(22071-22-3)

Safety Data

• Statements: 36/37/38
• Safety Statements: 26-36/37/39
• Hazardous Substances Data: 22071-22-3(Hazardous Substances Data)

Usage

Chemical Properties

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Uses

Different sources of media describe the Uses of 22071-22-3 differently. You can refer to the following data:
1. 3-Benzoylphenylacetic Acid shows antiinflammatory and analgesic activities and it can be used as neoplasm inhibitors and for treatment of angiogenesis-related disorders
2. Desmethyl Ketoprofen (Ketoprofen EP Impurity B) shows antiinflammatory and analgesic activities. It can be used as neoplasm inhibitors and for treatment of angiogenesis-related disorders.

InChI:InChI=1/C15H12O3/c16-14(17)10-11-5-4-8-13(9-11)15(18)12-6-2-1-3-7-12/h1-9H,10H2,(H,16,17)

Upstream product

• 21288-34-6 2-(3-benzoylphenyl)acetonitrile 
• 99-04-7 m-Toluic acid 
• 100884-27-3 4,6-dioxo-6-phenyl-hexanoic acid ethyl ester 
• 7664-93-9 sulfuric acid 
• 7440-44-0 pyrographite 
• 71-43-2 benzene 
• 1711-06-4 3-Methylbenzoyl chloride 
• 643-65-2 3-methyl benzophenone 
• 22071-24-5 3-benzoylbenzyl bromide 
• 74-88-4 methyl iodide 

Downstream Products

• 55142-46-6 [3-(1-Hydroxy-1-phenyl-ethyl)-phenyl]-acetic acid 
• 55142-43-3 (3-benzylphenyl)acetic acid 
• 55142-44-4 [3-(Hydroxy-phenyl-methyl)-phenyl]-acetic acid 
• 486407-26-5 tert-butyl 2-(3-benzoylphenyl)acetate 
• 24021-44-1 methyl (3-benzoylphenyl)acetate 
• 24021-52-1 sodium 3-benzoylphenylacetate 
• 55142-47-7 [3-(1-Phenyl-vinyl)-phenyl]-acetic acid 
• 116329-78-3 C₄₂H₅₆O₃ 
• 116329-76-1 C₄₃H₆₁NO₃ 
• 60695-28-5 {3-[2-(3-Dimethylamino-propylamino)-ethyl]-phenyl}-phenyl-methanone; hydrochloride 
• 60695-27-4 4-[2-(3-benzoylphenyl)ethyl]morpholine hydrochloride 
• 60695-23-0 2-cyclohexylmethyl-1-[(3-benzoylphenyl)acetyl]piperidine 
• 81597-85-5 N-(3-Dimethylamino-propyl)-2-[3-(2-phenyl-[1,3]dioxolan-2-yl)-phenyl]-acetamide 
• 81597-83-3 3-<2-morpholino-2-oxoethyl>benzophenone cyclic ethylene acetal 

Relevant articles and documents

Efficient photodecarboxylation of aroyl-substituted phenylacetic acids in aqueous solution: A general photochemical reaction

Photolysis (254-350 nm) of a variety of aroyl-substituted phenylacetic acids and p-acetylphenylacetic acid in aqueous solution at pH > pK(a) resulted in efficient photodecarboxylation (Φ = 0.2-0.7), to give in most cases a single product arising via the corresponding arylmethyl carbanion, indicating that photodecarboxylation is an efficient and general reaction for these types of compounds.

Esters and amides of substituted phenyl acetic acids

Esters and amides of substituted phenyl acetic acids having the formula wherein Q is a deprotonated residue of a polymer or macromolecular structure having a molecular weight of at least 1000 containing at least two primary and/or secondary amino groups and/or hydroxy groups;, n is an integer of at least 2;, R1 and R2 are independently selected from, hydrogen, halogen, alkyl, alkenyl, alkinyl or halo alkyl;, R3 is one or more substituents selected from halogen, alkyl, alkenyl or alkinyl, cycloalkyl, oxo-substituted alkylcycloalkyl, haloalkyl, alkoxy, alkenyloxy, alkinyloxy, alkylamino, alkenylamino, alkinylamino, alkysulfonyl, alkenylsulfonyl, alkinylsulfonyl, alkylsulfinyl, alkenylsulfinyl, alkinylsulfinyl, alkylsulfenyl, alkenylsulfenyl, alkinylsulfenyl, pyrrolyl, piperidinyl, benzoyl, imidazolpyridinyl, isoindolyl, oxo-substituted isoindolyl, thionylcarbonyl, phenyl, phenoxy and halo-substituted phenoxy, are useful in the treatment of colonic polyps.

ARENES FROM ALKANES OR CYCLOALKANES THROUGH DEHYDRATION OR REARRANGEMENT WITH PYRIDINIUM CHLORIDE

The preparations of various kinds of arylacetic acids both from the precursors and from the synthetic equivalents of (2-oxocyclohexenyl)acetic acids are reviewed.Particular attention is paid to the methods by which these intermediates can be obtained since the usefulness of the reaction is obviously bound to substrate availability.Further developments in the field of aromatic hydrocarbons and heterocyclic compounds are illustrated and a model for the reaction is proposed.In addition to the data already published in scientific journals and in the patent literature, several unpublished data are reported.