41658-12-2

Usage

InChI:InChI=1/C5H5ClO2/c1-8-5(7)3-2-4-6/h4H2,1H3

Upstream product

• 67-56-1 methanol 
• 13280-03-0 4-chlorobut-2-ynoic acid 
• 624-65-7 2-propynyl chloride 
• 79-22-1 methyl chloroformate 
• 201230-82-2 carbon monoxide 
• 13280-07-4 4-chlorobut-2-yn-1-ol 

Downstream Products

• 120722-73-8 3-(4-Bromo-phenyl)-5-chloromethyl-thiazolo[3,2-a]pyrimidin-7-one 
• 120722-66-9 6-Chlormethyl-2-methylthio-1-phenyl-pyrimidin-4(1H)-on 
• 110700-77-1 6-Chloromethyl-2-(4-nitro-phenyl)-1H-pyrimidin-4-one 
• 89639-37-2 6-Chlormethyl-2-methylthio-pyrimidin-4(1H)-on 
• 35252-98-3 6-Chloromethyl-2-phenyl-1H-pyrimidin-4-one 
• 120722-71-6 5-Chloromethyl-3-phenyl-thiazolo[3,2-a]pyrimidin-7-one 

Relevant academic research and scientific papers

Methoxycarbonylation of Acetylenic Compounds

A one-step procedure was developed for preparation of α,β-acetylenic γ-hydroxycarboxylic acid methyl esters with high yields by methoxycarbonylation of acetylenic alcohols with carbon monoxide in the presence of the catalytic system PdCl2-CuCl2-NaOAc (molar ratio methanol-acetylenic alcohol-PdCl2-CuCl2-NaOAc 5:0.02:0.0006:0.07:0.07). Methyl 4-methyl-4-hydroxy-2-pentynoate can be synthesized in the presence of CuCl2-NaOAc with no palladium.

A Simple and Efficient Synthesis of Chlorotetrolic Esters

Treatment of propargyl chloride with methyl-lithium and an excess of alkyl chloroformate leads to chlorotetrolic esters in an average yield of 65percent, in contrast with the previously reported three-step, low-yield synthesis of these biochemical reagents.