41661-49-8Relevant academic research and scientific papers
Highly chemoselective reductive amination of carbonyl compounds promoted by InCl3/Et3SiH/MeOH system
Lee, On-Yi,Law, Ka-Lun,Ho, Chun-Yu,Yang, Dan
experimental part, p. 8829 - 8837 (2009/04/05)
(Chemical Equation Presented) A new strategy has been developed for reductive amination of aldehydes and ketones with the InCV Et 3SiH/MeOH system, which is a nontoxic system with highly chemoselective and nonwater sensitive properties. The methodology can be applied to a variety of cyclic, acyclic, aromatic, and aliphatic amines. Functionalities including ester, hydroxyl, carboxylic acid, and olefin are found to be stable under our conditions. The reaction shows a first-order kinetics profile with respect to both InCl3 and Et3SiH. Spectroscopic techniques such as NMR and ESI-MS have been employed to probe the active and resulting species arising from InCl3 and Et3SiH in MeOH, which are important in deriving a mechanistic proposal. In the ESI-MS studies, we have first discovered the existence of stable methanol-coordinated indium(III) species which are presumably responsible for the gentle generation of indium hydride at room temperature. The solvent attribution was crucial in tuning the reactivity of [In-H] species, leading to the establishment of mild reaction conditions. The system is superior in flexible tuning of hydride reactivity, resulting in the system being highly chemoselective.
Potent and selective ligands for the dopamine transporter (DAT): Structure-activity relationship studies of novel 4-[2- (diphenylmethoxy)ethyl]-1-(3-phenylpropyl)piperidine analogues
Dutta, Aloke K.,Coffey, Lori L.,Reith, Maarten E.A.
, p. 699 - 705 (2007/10/03)
Molecular structural modifications of 4-[2-(diphenylmethoxy)ethyl]- 1- (3-phenylpropyl)piperidine (1a), a dopamine transporter (DAT)-specific ligand, generated several novel analogues. Biological activities of these new molecules for their binding to the
