41727-47-3

Usage

Uses

Used in Chemical Synthesis:
METHYL 3,5-DIBROMO-4-HYDROXYBENZOATE is used as a chemical intermediate for the production of 4-hydroxy-3,5-di-pyridin-2-yl-benzoic acid methyl ester. This synthesis process typically occurs at a temperature range of 90-100°C, allowing for the formation of the desired compound with specific properties and applications.
While the provided materials do not specify the exact applications of the final product, 4-hydroxy-3,5-di-pyridin-2-yl-benzoic acid methyl ester, it can be inferred that METHYL 3,5-DIBROMO-4-HYDROXYBENZOATE may have potential uses in various industries such as pharmaceuticals, materials science, or as a specialty chemical. Further research and development would be necessary to explore the specific applications and benefits of this synthesized compound.

InChI:InChI=1/C8H6Br2O3/c1-13-8(12)4-2-5(9)7(11)6(10)3-4/h2-3,11H,1H3

Upstream product

• 67-56-1 methanol 
• 3337-62-0 3,5-dibromo-4-hydroxybenzoic acid 
• 99-76-3 methyl 4-hydroxylbenzoate 
• 99-96-7 4-hydroxy-benzoic acid 
• 186581-53-3 diazomethane 
• 1033756-59-0 3,5-dibromo-4-(di-tert-butyl((2E,6E,10E,14E,18E)-2,6,10,15,19,23-hexamethyltetracosa-2,6,10,14,18,22-hexaenyloxy)silyloxy)benzoic acid 
• 1033756-53-4 3,5-dibromo-4-(di-tert-butyl(nonaprenyloxy)silyloxy)benzoic acid 

Downstream Products

• 59099-93-3 3,5-Dibromo-4-hexadecyloxy-benzoic acid methyl ester 
• 107355-56-6 3,5-Dibromo-4-hydroxy-N-(2-hydroxy-ethyl)-benzamide 
• 55182-66-6 2-(3,5-dibromo-4-hydroxyphenyl)-2-propanol 
• 858950-47-7 methyl 4-hexyloxy-3,5-dibromobenzoate 
• 1033756-17-0 methyl 3,5-dibromo-4-(di-tert-butyl((2E,6E,10E)-3,7,11,15-tetramethylhexadeca-2,6,10,14-tetraenyloxy)silyloxy)benzoate 
• 72415-59-9 4-acetoxy-3,5-dibromobenzoic acid 
• 22812-61-9 methyl 3,5-dibromo-4-methoxybenzoate 
• 501657-81-4 3,5-dibromo-4-benzyloxybenzoic acid 
• 4073-36-3 3,5-dibromo-4-methoxybenzoyl chloride 
• 4073-35-2 3,5-dibromo-4-methoxybenzoic acid 

Relevant academic research and scientific papers

A chemical probe for the estrogen receptor: Synthesis of the 3H-isotopomer of raloxifene

Radiolabelled raloxifene (LY156758) has been prepared by tritium gas hydrogenolysis of a 3-aroyl-bis-brominated precursor. The requisite halogenated intermediate was accessed by regioselective aroylation of benzothiophene 6 with the acid chloride of 3,5-dibromo-4-[2-(1-piperdinyl)ethoxy]benzoic acid (5). Selective deprotection of the aryl methyl ethers in the presence of the ethoxy side-chain followed by palladium catalyzed halogen-tritium exchange provided the target compound with a specific activity of 30.1 Ci/mmol.

IMPROVED PROCESSES FOR THE PREPARATION OF SOFOSBUVIR AND INTERMEDIATES THEREOF

The present disclosure provides new procedures and intermediates for the preparation of Sofosbuvir.

A strategy for position-selective epoxidation of polyprenols

An effective strategy has been developed for the efficient site-selective epoxidation of poylolefinic isoprenoid alcohols, based on the use of an internal control element for intramolecular reaction. The approach is illustrated by application to a series of polyisoprenoid alcohols (polyprenols) at substrate concentration of 0.5 mM. With polyprenol substrates having the hydroxyl function at one terminus, the internal epoxidation can be directed at the double bond of the polyprenol, which is either four or five away from the terminal hydroxyprenyl subunit.

Synthesis of binucleating ligands of pyridylphenol

The synthesis of pyridylphenol-type dinucleating tri- and penta-dentate ligands has been accomplished by cross-couplings.