4173-84-6

Upstream product

• 18982-48-4 1-(p-Acetamidophenyl)-2-nitropropen 
• 855444-67-6 C₁₂H₁₆N₂O₃ 
• 917-54-4 methyllithium 
• 539-03-7 N-(4-chlorophenyl)acetamide 
• 67-64-1 acetone 
• 122-85-0 para-acetamidobenzaldehyde 
• 103-88-8 4-bromoacetanilide 
• 15435-71-9 sodium acetylacetonate 

Downstream Products

• 1092775-89-7 1-chloro-1-(4-acetamidophenyl)propan-2-one 
• 855444-68-7 C₁₁H₁₂N₂O₄ 
• 90514-85-5 N-[4-(5-cyano-1,6-dihydro-2-methyl-6-oxo-3-pyridinyl)-phenyl]-acetamide 
• 108122-71-0 5-<4-(4,5-dihydro-1H-imidazol-2-yl)phenyl>-6-methyl-2(2H)-pyridone 
• 108122-70-9 4-(1,6-dihydro-2-methyl-6-oxo-3-pyridinyl)benzenecarbothioamide 
• 108122-69-6 4-(1,6-dihydro-2-methyl-6-oxo-3-pyridinyl)benzonitrile 

Relevant academic research and scientific papers

Palladium-catalyzed mono-α-arylation of acetone with aryl halides and tosylates

We report the first example of selective Pd-catalyzed mono-α- arylation of acetone employing aryl chlorides, bromides, iodides, and tosylates. The use of appropriately designed P,N-ligands proved to be the key to controlling the reactivity and selectivity. The reaction affords good yields with substrates containing a range of functional groups at modest Pd loadings using Cs2CO3 as the base and employing acetone as both a reagent and the solvent.(Figure Presented)

SUBSTITUTED 6-CYCLOHEXYLALKYL SUBSTITUTED 2-QUINOLINONES AND 2-QUINOXALINONES AS POLY(ADP-RIBOSE) POLYMERASE INHIBITORS

The present invention provides compounds of formula (I), their use as PARP inhibitors as well as pharmaceutical compositions comprising said compounds of formula (I) wherein n, s, R1, R2, R3, Q, X and Y have defined meanin

Substituted phenyl-pyridinones as cardiotonic agents

Certain 2(1H)-pyridinones are cardiotonic agents. Methods for their preparation and use are disclosed.

A VERSATILE SYNTHESIS OF ARYLACETONES FROM ARYL HALIDES AND ACETYLACETONATE

Reaction of aryl halides with sodium or potassium acetylacetonate in the presence of a copper catalyst affords directly arylacetones resulted from deacetylation of initially formed 3-arylacetylacetones in good yields.