41731-52-6

Usage

Uses

Used in Pharmaceutical Industry:
ETHYL 2-CHLORO-1,3-THIAZOLE-4-CARBOXYLATE is used as an intermediate in the synthesis of various pharmaceuticals. Its unique chemical structure allows it to be incorporated into the development of new drugs, potentially contributing to the treatment of various medical conditions.
Used in Agrochemical Industry:
In the agrochemical sector, ETHYL 2-CHLORO-1,3-THIAZOLE-4-CARBOXYLATE serves as a key intermediate in the production of pesticides and other agrochemicals. Its incorporation into these products can enhance their effectiveness in controlling pests and diseases, thereby improving crop yields and food security.
Used in Chemical Research:
ETHYL 2-CHLORO-1,3-THIAZOLE-4-CARBOXYLATE is also utilized in chemical research for the exploration of new chemical reactions and the synthesis of novel compounds. Its unique properties make it a valuable tool for scientists in advancing the understanding of chemical processes and developing innovative applications.

Upstream product

• 5398-36-7 2-aminothiazole-4-carboxylate 
• 1001-26-9 ethyl 3-ethoxyacrylate 
• 70-23-5 ethyl Bromopyruvate 

Downstream Products

• 5198-87-8 2-chlorothiazole-4-carboxylic acid 
• 101012-12-8 2-chloro-1,3-thiazole-5-carboxylic acid 
• 57677-79-9 ethyl 2-(4-methoxyphenyl)thiazole-4-carboxylate 
• 132089-35-1 ethyl 2-(4-fluorophenyl)thiazole-4-carboxylate 
• 175204-88-3 2-[4-(trifluoromethyl)phenyl]thiazole-4-carboxylic acid ethyl ester 
• 922516-49-2 ethyl 2-(1-piperazinyl)-4-thiazolecarboxylate monohydrochloride 
• 660449-97-8 ethyl 2-(3-(((tert-butoxycarbonyl)amino)methyl)-2-isobutyl-4-(4-methylphenyl)quinolin-6-yl)-1,3-thiazole-4-carboxylate 
• 1392426-83-3 ethyl 2-[(1,3-benzodioxol-5-ylmethyl)(cyclohexyl)amino]-1,3-thiazole-4-carboxylate 
• 928256-35-3 2-chlorothiazol-4-carboxamide 
• 153027-86-2 ethyl 2-fluorothiazole-4-carboxylate 
• 5198-85-6 (2-chlorothiazol-4-yl)methanol 
• 867065-53-0 4-(4-ethoxycarbonylthiazol-2-yl)piperazine-1-carboxylic acid tert-butyl ester 

Relevant academic research and scientific papers

HETEROCYCLIC AMINOBERBAMINE DERIVATIVES, THE PREPARATION PROCESS AND USE THEREOF

The present invention relates to a novel berbamine derivative of formula I or a pharmaceutically acceptable salt thereof, a process for preparation of the same, a pharmaceutical composition comprising said compound and its use in manufacture of an antitumor medicament.

Photoredox-mediated C-H functionalization and coupling of tertiary aliphatic amines with 2-chloroazoles

Herein, conditions for C-H functionalization of tertiary aliphatic amines and their subsequent coupling with a number of 2-chloroazole derivatives are reported. The reaction is facilitated by a catalytic amount of tris-fac-Ir(ppy)3, with blue light irradiation and takes place under mild and convenient conditions. Most couplings take place with excellent regioselectivity. The reaction is tolerant of a number of functional groups and allows for rapid access to α-azole carbinamines commonly found in post-translationally modified peptides.

Tuning and predicting biological affinity: Aryl nitriles as cysteine protease inhibitors

A series of aryl nitrile-based ligands were prepared to investigate the effect of their electrophilicity on the affinity against the cysteine proteases rhodesain and human cathepsin L. Density functional theory calculations provided relative reactivities of the nitriles, enabling prediction of their biological affinity and cytotoxicity and a clear structure-activity relationship.

NUCLEAR TRANSPORT MODULATIORS AND USES THEREOF

The invention generally relates to the field of nuclear transport modulators, e.g., CRM1 inhibitors, and more particularly to new substituted-heterocyclic azole compounds, the synthesis and use of these compounds and their pharmaceutical compositions, e.g

Dihydropyrimidine Compounds and Their Uses in Preparation of Medicaments for Treating and Preventing Antiviral Diseases

The present invention relates to a compound of formula (I) or a pharmaceutically acceptable salt or hydrate thereof, to a process for preparing the compound of formula (I), and to use of the compound of formula (I) or a pharmaceutically acceptable salt or

DIHYDROPYRIMIDINE COMPOUNDS AND THEIR USES IN PREPARATION OF MEDICAMENTS FOR TREATING AND PREVENTING ANTIVIRAL DISEASES

The present invention relates to a compound of formula (I) or a pharmaceutically acceptable salt or hydrate thereof, to a process for preparing the compound of formula (I), and to use of the compound of formula (I) or a pharmaceutically acceptable salt or hydrate thereof as a medicament, in particular as a medicament for the treatment and prevention of type B hepatitis.

NOVEL PIPERAZINES, PHARMACEUTICAL COMPOSITIONS AND METHODS OF USE THEREOF

Disclosed are novel piperazine derivatives that act as agonists of the α7 nAChR. Also disclosed are phannaceutical compositions, methods of treating inflammatory conditions, methods of treating CNS disorders, methods for inhibiting cytokine release from mammalian cells and methods for the preparation of the novel compounds.

EP2 RECEPTOR AGONISTS

A compound of Formula (I) or a salt, solvate and chemically protected form thereof, wherein: R5 is an optionally substituted C5-20 aryl or C4-20 alkyl group; A is selected from the group consisting of Formulae (Ai), (Aii), (Aiii) D is selected from Formulae (Di), (Dii), (Diii), (Div), (Dv) B is selected from the group consisting of Formulae (Bi), (Bii), (Biii), (Biv) (Bv).

MALONONITRILE COMPOUND AS PESTICIDES

The present invention provides a malononitrile compound represented by the formula (I): wherein any one of X1, X2, X3 and X4 is CR100, wherein R100 is a group represented by the formula: the other three of X1, X2, X3 and X4 each represent nitrogen or CR5, provided that 1 to 3 of X1, X2, X3 and X4 represent nitrogen, and Z represents oxygen, sulfur or NR6, which has pest-controlling activity.

4-[(4-(CARBOXYETHYL) PIPERIDINYL) METHYL] PYRROLIDINES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY

3-Substituted pyrrolidines having a 4-carboxypiperidinylmethyl substituent on the 4-position of the ring are useful as modulators of chemokine receptor activity. In particular, these compounds are useful as modulators of the chemokine receptors CCR-3 and/or CCR-5.