54045-76-0

Basic information

• Product Name: 2-Bromo-5-thiazolecarboxylic acid
• Synonyms: 2-BROMO-1,3-THIAZOLE-5-CARBOXYLIC ACID;2-BROMO-5-THIAZOLECARBOXYLIC ACID;2-BROMOTHIAZOLE-5-CARBOXYLIC ACID;RARECHEM AL BE 1435;2-BROMO-5-THLAZOLECARBOXYLIC ACID;2-Bromo-1,3-thiazole-5-carboxylic acid 97%;2-BROMOTHAIZOLE-5-CARBOXYLIC ACID;5-Thiazolecarboxylicacid, 2-broMo-
• CAS NO: 54045-76-0
• Molecular Formula: C₄H₂BrNO₂S
• Molecular Weight: 208.03
• EINECS: 1592732-453-0
• Product Categories: blocks;Bromides;Carboxes;Thiazoles;Carboxylic Acids;Thiazoles, Isothiazoles &Benzothiazoles;Organic acids;Building Blocks;Thiazole;Carboxylic Acids;Thiazoles, Isothiazoles & Benzothiazoles;Building Blocks;Halogenated Heterocycles;Heterocyclic Building Blocks;ThiazolesHeterocyclic Building Blocks
• Mol File: 54045-76-0.mol
• Article Data: 9

Chemical Properties

• Melting Point: 182 °C (dec.)
• Boiling Point: 350 °C at 760 mmHg
• Flash Point: 165.5 °C
• Appearance: White to off-white/Crystalline Powder
• Density: 2.062 g/cm³
• Vapor Pressure: 1.69E-05mmHg at 25°C
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• PKA: 2.52±0.10(Predicted)
• CAS DataBase Reference: 2-Bromo-5-thiazolecarboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Bromo-5-thiazolecarboxylic acid(54045-76-0)
• EPA Substance Registry System: 2-Bromo-5-thiazolecarboxylic acid(54045-76-0)

Safety Data

• Hazard Codes: Xi
• Statements: 43
• Safety Statements: 36/37
• WGK Germany: 3
• Hazardous Substances Data: 54045-76-0(Hazardous Substances Data)

Usage

Chemical Properties

White to brown solid

Uses

2-Bromothiazole-5-carboxylic acid is used as a reagent to synthesize azole-based protein kinase B inhibitors, some of which have anti-cancer properties.

InChI:InChI=1/C4H2BrNO2S/c5-4-6-1-2(9-4)3(7)8/h1H,(H,7,8)/p-1

Upstream product

• 54045-74-8 methyl 2-bromo-1,3-thiazole-5-carboxylate 
• 41731-83-3 ethyl 2-bromo-1,3-thiazole-5-carboxylate 

Downstream Products

• 302964-07-4 2-bromo-N-(2-chloro-6-methylphenyl)-1,3-thiazole-5-carboxamide 
• 148637-74-5 2-chloro-1,3-thiazole-5-carbonyl chloride 
• 857982-30-0 2-Oxo-2,3-dihydrothiazole-5-carboxylic acid 
• 1209458-80-9 2-bromo-5-(trifluoromethyl)-1,3-thiazole 
• 941716-91-2 2-(pyrrolidin-1-yl)thiazole-5-carboxylic acid 

Relevant articles and documents

FLUOROALKYL-OXADIAZOLES AND USES THEREOF

Provided herein are compounds identified as inhibitors of HDAC6 activity that can be used to treat various diseases and disorders.

SUBSTITUTED BICYCLIC HETEROARYL COMPOUNDS

Disclosed are compounds of Formula (I) N-oxides, or salts thereof, wherein X, Y, A, G, R1, and R5 are defined herein. Also disclosed are methods of using such compounds as inhibitors of signaling through Toll-like receptor 7, or 8, or 9, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating inflammatory and autoimmune diseases.

SUBSTITUTED NITROGEN CONTAINING COMPOUNDS

Disclosed are compounds of Formula (I): or a salt thereof, Formula (II) wherein R1 is: or; each W is independently NR1b or O; Z is a bond or CHR1d; and R1, R2, Rd, R3a, R3b, L1, B, V, Y, and n are defined herein. Also disclosed are methods of using such compounds as inhibitors of ROMK, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating cardiovascular diseases.