41735-81-3Relevant academic research and scientific papers
A safe and economical synthesis of 3-(trifluoromethoxy) aniline from 2-chlorophenol
Langlois, Bernard,Soula, Gerard
, p. 925 - 929 (2007/10/02)
A simple, safe and realistic synthesis of 3-(trifluoromethoxy) aniline from 2-chlorophenol is proposed, the key step being a regiospecific arynic amination of 2-chloro (trifluoromethoxy) benzene.This method has been extended to the synthesis of 4-chloro-3-(trifluoromethoxy) aniline from 2,6-dichlorophenol.Some unusual products are obtained during the reaction between sodium amide and 2-chloro (chlorodifluoromethoxy) benzene, the formation of which is discussed.
