41743-56-0

Usage

Uses

Used in Pharmaceutical Industry:
Luteone is used as a potential therapeutic agent for various health conditions due to its medicinal properties. It is being studied for its potential to influence hormonal activity, which could be beneficial in treating hormonal imbalances or related disorders.
Used in Anti-Inflammatory Applications:
Luteone is used as an anti-inflammatory agent, which can help reduce inflammation and alleviate pain in various medical conditions. Its anti-inflammatory properties make it a promising candidate for the development of new treatments for inflammatory diseases.
Used in Cancer Prevention and Treatment:
Luteone is used as a potential cancer-preventing and cancer-treating agent. Its ability to potentially prevent tumor growth and influence hormonal activity suggests that it could be a valuable component in cancer prevention strategies and as an adjunct to conventional cancer treatments.
Used in Alzheimer's Disease Research:
Luteone is used as a potential therapeutic agent in the treatment of Alzheimer's disease. Laboratory studies have suggested that it may have beneficial effects on the condition, but more research is needed to fully understand its potential role in Alzheimer's disease treatment.
Used in Plant Defense Mechanisms:
Luteone is used as a natural defense mechanism in plants, helping them protect themselves against pathogens or predators. Understanding the role of luteone in plant defense could lead to the development of new strategies for plant protection and crop improvement.

InChI:InChI=1/C20H18O6/c1-10(2)3-5-13-16(23)8-17-18(19(13)24)20(25)14(9-26-17)12-6-4-11(21)7-15(12)22/h3-4,6-9,21-24H,5H2,1-2H3

Upstream product

• 91681-62-8 2',4',5,7-tetrahydroxy-6-(3-hydroxy-3-methylbutyl)isoflavone 
• 115-19-5 2-methyl-but-3-yn-2-ol 
• 358-72-5 dimethylallyl diphosphate 
• 1156-78-1 2',4',5,7-tetrahydroxyisoflavone 
• 321569-98-6 2',4',5,7-tetrakis(benzyloxy)-6-(3-hydroxy-3-methyl-1-butynyl)isoflavone 
• 1027232-20-7 acetic acid 3,5-bis-benzyloxy-2-[2-(2,4-bis-benzyloxy-phenyl)-3,3-dimethoxy-propionyl]-4-iodo-phenyl ester 
• 844868-34-4 6'-acetoxy-2,4,2',4'-tetrakis(benzyloxy)-3'-iodochalcone 
• 321570-04-1 2',4',7-tris(benzoyloxy)-6-(3-hydroxy-3-methylbutyl)-5-tosyloxyisoflavone 
• 321570-10-9 2',4',7-tris(benzoyloxy)-6-(3-methyl-2-butenyl)-5-tosyloxyisoflavone 
• 321569-92-0 1-[6-benzoyloxy-2,4-bis(benzyloxy)-3-iodophenyl]-2-[2,4-bis(benzyloxy)phenyl]-3,3-dimethoxypropan-1-one 
• 321569-89-5 2,4,2',4'-tetrakis(benzyloxy)-6'-benzoyloxy-3'-iodochalcone 
• 321570-01-8 2',4',7-tris(benzoyloxy)-5-hydroxy-6-(3-hydroxy-3-methylbutyl)isoflavone 
• 321569-86-2 2,4,2',4'-tetrakis(benzyloxy)-6'-hydroxy-3'-iodochalcone 
• 321569-95-3 2',4',5,7-tetrakis(benzyloxy)-6-iodoisoflavone 

Downstream Products

• 91681-64-0 6-(2,4-Dihydroxy-phenyl)-4-hydroxy-2-(1-hydroxy-1-methyl-ethyl)-2,3-dihydro-furo[3,2-g]chromen-5-one 
• 136337-77-4 2,6,8-Trihydroxy-7-((E)-4-hydroxy-3-methyl-but-2-enyl)-10,11-dioxa-benzo[b]fluoren-5-one 
• 136337-76-3 (E)-4-[3-(2,4-Dihydroxy-phenyl)-5,7-dihydroxy-4-oxo-4H-chromen-6-yl]-2-methyl-but-2-enoic acid 
• 136337-75-2 (Z)-hydroxyluteone 
• 136337-79-6 3-(2,4-Dihydroxy-phenyl)-5,7-dihydroxy-6-(4-hydroxy-3-hydroxymethyl-but-2-enyl)-chromen-4-one 
• 91681-63-9 6-(2,3-Dihydroxy-3-methyl-butyl)-3-(2,4-dihydroxy-phenyl)-5,7-dihydroxy-chromen-4-one 
• 41628-68-6 2',4',5,7-tetraacetoxy-6-(3-methyl-2-butenyl)isoflavone 

Relevant academic research and scientific papers

Molecular Characterization and Phylogenetic Analysis of Two Novel Regio-specific Flavonoid Prenyltransferases from Morus alba and Cudrania tricuspidata

Prenylated flavonoids are attractive specialized metabolites with a wide range of biological activities and are distributed in several plant families. The prenylation catalyzed by prenyltransferases represents a Friedel-Crafts alkylation of the flavonoid skeleton in the biosynthesis of natural prenylated flavonoids and contributes to the structural diversity and biological activities of these compounds. To date, all identified plant flavonoid prenyltransferases (FPTs) have been identified in Leguminosae. In the present study two new FPTs, Morus alba isoliquiritigenin 3′-dimethylallyltransferase (MaIDT) and Cudrania tricuspidata isoliquiritigenin 3′-dimethylallyltransferase (CtIDT), were identified from moraceous plants M. alba and C. tricuspidata, respectively. MaIDT and CtIDT shared low levels of homology with the leguminous FPTs. MaIDT and CtIDT are predicted to be membrane-bound proteins with predicted transit peptides, seven transmembrane regions, and conserved functional domains that are similar to other homogentisate prenyltransferases. Recombinant MaIDT and CtIDT were able to regioselectively introduce dimethylallyl diphosphate into the A ring of three flavonoids with different skeleton types (chalcones, isoflavones, and flavones). Phylogenetic analysis revealed thatMaIDT and CtIDT are distantly related to their homologs in Leguminosae, which suggests that FPTs in Moraceae and Leguminosae might have evolved independently. MaIDT and CtIDT represent the first two non-Leguminosae FPTs to be identified in plants and could thus lead to the identification of additional evolutionarily varied FPTs in other non-Leguminosae plants and could elucidate the biosyntheses of prenylated flavonoids in various plants. Furthermore, MaIDT and CtIDT might be used for regiospecific prenylation of flavonoids to produce bioactive compounds for potential therapeutic applications due to their high efficiency and catalytic promiscuity.

Regioselective synthesis of 6-alkyl- and 6-prenylpolyhydroxyisoflavones and 6-alkylcoumaronochromone derivatives

The palladium-catalyzed coupling reaction of 6-iodoisoflavone, prepared from 3′-iodoacetophenone derivative, with 2-methyl-3-butyn-2-ol gave 6-alkynylisoflavone derivative, which was hydrogenated to give 6-alkylhydroxyisoflavone (luteone hydrate) (2). Dehydration of 2 gave 2′,4′,5,7-tetrahydroxy-6-prenylisoflavone (luteone) (1). Wighteone hydrate (3) was also synthesized from 6-iodotris(benzyloxy)isoflavone in a similar manner. 6-Alkyl-4′5,7-trihydroxy-coumaronochromone (4) was synthesized by oxidative cyclization of 2 with o-chloranil.

Regioselective synthesis of prenylisoflavones: Syntheses of luteone and luteone hydrate

The palladium-catalyzed coupling reaction of 6-iodoisoflavone, prepared from 3′-iodoacetophenone derivative, with 2-methyl-3-butyn-2-ol gave the 6-alkynylisoflavone derivative, which was hydrogenaied to give the 6-alkylhydroxyisoflavone (luteone hydrate)