4176-70-9

Basic information

• Product Name: 2-(morpholin-4-yl)-1,2-diphenylethanol
• CAS NO: 4176-70-9
• Molecular Formula: C₁₈H₂₁NO₂
• Molecular Weight: 283.3648
• Mol File: 4176-70-9.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 408.1°C at 760 mmHg
• Flash Point: 200.6°C
• Density: 1.165g/cm³
• Vapor Pressure: 2.16E-07mmHg at 25°C
• Refractive Index: 1.602
• CAS DataBase Reference: 2-(morpholin-4-yl)-1,2-diphenylethanol(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(morpholin-4-yl)-1,2-diphenylethanol(4176-70-9)
• EPA Substance Registry System: 2-(morpholin-4-yl)-1,2-diphenylethanol(4176-70-9)

Safety Data

• Hazardous Substances Data: 4176-70-9(Hazardous Substances Data)

Usage

General Description

2-(morpholin-4-yl)-1,2-diphenylethanol is a chemical compound with a molecular formula C20H23NO2. It is a diphenylethanol derivative with a morpholine group attached to one of the phenyl rings. 2-(morpholin-4-yl)-1,2-diphenylethanol has potential biological activity, specifically as an antagonist for the opioid receptor. It may also have potential as a therapeutic agent for the treatment of opioid addiction or as an analgesic. Further research and development of this compound could lead to the discovery of new medications for the management of pain and addiction. Additionally, it may have applications in the field of medicinal chemistry for the synthesis of novel pharmaceuticals.

Upstream product

• 110-91-8 morpholine 
• 1689-71-0 cis-1,2-diphenyloxirane 
• 1439-07-2 trans-Stilbene oxide 

Downstream Products

• 122687-97-2 meso-4,4'-(1,2-Diphenylethylen)bis 
• 110-91-8 morpholine 
• 100-52-7 benzaldehyde 
• 107576-76-1 1-methoxy-2-morpholino-1,2-diphenylethane 

Relevant articles and documents

Hydrogen Bonding Phase-Transfer Catalysis with Potassium Fluoride: Enantioselective Synthesis of β-Fluoroamines

Potassium fluoride (KF) is an ideal reagent for fluorination because it is safe, easy to handle and low-cost. However, poor solubility in organic solvents coupled with limited strategies to control its reactivity has discouraged its use for asymmetric C-F

Oxidative photofragmentation of α,β-amino alcohols via single electron transfer: Cooperative reactivity of donor and acceptor ion radicals in photogenerated contact radical ion pairs

The studies presented in this paper show that α,β-amino alcohols undergo a very clean C-C bond cleavage upon SET (single electron transfer) oxidation by photoexcited electron acceptors in a process which generally culminates in two-electron reduction of the acceptors. For a number of different α,β-amino alcohols, the oxidative fragmentation occurs in a high chemical yield (>90%), yet with low to medium quantum efficiencies (0.0001-0.1) which vary strongly depending on the properties of electron donor (D), acceptor (A), and solvent. The net quantum efficiency reflects the competition between back electron transfer and the chemical redox process. Detailed mechanistic studies were carried out to investigate the visible light induced oxidative fragmentation of α,β-amino alcohols in the presence of electron acceptors including, thioindigo (TI), 9,10-dicyanoanthracene (DCA), 2,6,9,10-tetracyanoanthracene (TCA), and 1,4-dicyanonaphthalene (DCN). Cosensitized (biphenyl) photoredox leads to free ions, A- and D+, and moderately efficient unassisted fragmentation of D+. Quenching of 1A* by electron donor (D) to give a solvent separated radical ion pair (SSRIP) leads to a very inefficient reaction. In contrast, quenching to give a contact radical ion pair (CRIP) gives a relatively efficient reaction. This reaction is sensitive to the stereochemistry of the amino alcohol, suggesting a preferred anticoplanar configuration during the C-C bond cleavage process. The critical matching of reactivity of acceptor and donor ion radicals allows a rapid reaction to occur in the relatively narrow time window between formation and decay of the contact radical ion pair.