417702-90-0

Upstream product

• 97777-87-2 4-hydroxy-p-menthan-9-oic acid 
• 108-24-7 acetic anhydride 
• 589-92-4 1-methylcyclohexan-4-one 
• 598-72-1 2-Bromopropionic acid 
• 762-04-9 phosphonic acid diethyl ester 
• 31538-46-2 4-hydroxy-p-menthan-9-oic acid ethyl ester 

Downstream Products

• 91738-69-1 1-ethylidene-4-methyl-cyclohexane 
• 589-92-4 1-methylcyclohexan-4-one 

Relevant academic research and scientific papers

Synthesis and biological evaluation of cycloalkylidene carboxylic acids as novel effectors of Ras/Raf interaction

The protooncogenes Ras and Raf play important roles in signal transduction pathways regulated by mitogen-activated protein kinases. Mutations of Ras that arrest the protein in its active state are frequently implicated in tumor formation. We used Ras and Raf proteins in the yeast two-hybrid system to search for natural or synthesized substances capable of modulating Ras/Raf interaction by specifically binding to one of the interacting partners. We found that cycloalkylidene carboxylic acids enhanced Ras/Raf interaction by acting on the cysteine-rich domain of Raf. Several analogues of the active substance 2-cyclohexylidene propanoic acid were synthesized and the importance of the semicyclic double bond in the stabilization of Ras/Raf interaction was demonstrated. Variation of the size and the substituents of the cyclic system as well as the length of the carboxylic acid resulted in enhanced Ras/Raf interaction.