417721-36-9

Basic information

• Product Name: 4-chloro-7-Methoxyquinoline-6-carboxaMide
• Synonyms: 4-chloro-7-Methoxyquinoline-6-carboxaMide;4-chloro-7-Methoxy-6-QuinolinecarboxaMide;6-QuinolinecarboxaMide, 4-chloro-7-Methoxy-;Lenvatinib Impurity b;4-Chloro-7-methoxy-quinoline-6-carboxylic acid amide;4-Chloro-7-methoxyquinazoline-6-carboxamide;lenvaint-E
• CAS NO: 417721-36-9
• Molecular Formula: C₁₁H₉ClN₂O₂
• Molecular Weight: 236.65436
• EINECS: -0
• Mol File: 417721-36-9.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 426.7±45.0 °C(Predicted)
• Appearance: /
• Density: 1.380±0.06 g/cm3(Predicted)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• Solubility: DMSO (Slightly), Methanol (Slightly)
• PKA: 15.28±0.30(Predicted)
• CAS DataBase Reference: 4-chloro-7-Methoxyquinoline-6-carboxaMide(CAS DataBase Reference)
• NIST Chemistry Reference: 4-chloro-7-Methoxyquinoline-6-carboxaMide(417721-36-9)
• EPA Substance Registry System: 4-chloro-7-Methoxyquinoline-6-carboxaMide(417721-36-9)

Safety Data

• Hazardous Substances Data: 417721-36-9(Hazardous Substances Data)

Usage

Chemical Properties

light yellow powder

Uses

Pharmaceutical Intermediates. 4-chloro-7-Methoxyquinoline-6-carboxaMide is used as an intermediate for synthesizing Lenvatinibis.

Upstream product

• 67608-58-6 4-cyano-3-hydroxy-aniline 

Downstream Products

• 417721-38-1 6-carbamoyl-4-(4-amino-3-fluorophenoxy)-7-methoxyquinoline 
• 417722-93-1 4?(4?amino?3?chlorophenoxy)?7?methoxyquinoline?6?carboxamide 
• 417716-92-8 lenvatinib 

Relevant articles and documents

A [...] synthetic method

The invention provides a method of synthesizing [...]. First of all the invention to 4 - cyano - 3 - hydroxy aniline as the starting material, by dimethyl carbonate methylation, after third acid in the oximation reaction at room temperature, the conditions in the PPA shut-ring forms the 6 - cyano - 7 - methoxy - 4 - quinolinone, in thionyl chloride formed under the action of the 6 - cyano - 7 - methoxy - 4 - [...], under acidic conditions [...] cyano hydrolysis synthesis of one of the intermediates 6 - formamido - 7 - methoxy - 4 - chloroquinolin. Then the 4 - hydroxy - 2 chloroaniline with cyanogen bromide at low temperature 4 - hydroxy - 2 - chloro cyaniding amine, the 4 - hydroxy - 2 - chloro cyaniding amine with bearing-displacement generating Reeth reaction synthesis [...] another key intermediate 1 - (2 - chloro - 4 - hydroxy-phenyl) - 3 - ring propyl urea. Finally the two intermediate 6 - formamido - 7 - methoxy - 4 - chloroquinolin and 1 - (2 - chloro - 4 - hydroxy-phenyl) - 3 - ring propyl urea in the alkaline environment for carrying out the alkylation reaction [...]. This scheme has mild reaction conditions, no highly toxic reagent, environmental protection and the like.