4-chloro-7-Methoxyquinoline-6-carboxaMide

Base Information

Chemical Name:4-chloro-7-Methoxyquinoline-6-carboxaMide
CAS No.:417721-36-9
Molecular Formula:C11H9ClN2O2
Molecular Weight:236.658
Hs Code.:2933499090
Mol file:417721-36-9.mol

Synonyms:7-methoxy-4-chloro-quinoline-6-carboxamide;4-chloro-7-methoxy-quinoline-6-carboxylic acid amide;QC-5355;6-Quinolinecarboxamide,4-chloro-7-methoxy;

Suppliers and Price of 4-chloro-7-Methoxyquinoline-6-carboxaMide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
4-Chloro-7-methoxy-6-quinolinecarboxamide
1g
$ 85.00

SynQuest Laboratories
4-Chloro-7-methoxyquinoline-6-carboxamide 97%
5 g
$ 160.00

SynQuest Laboratories
4-Chloro-7-methoxyquinoline-6-carboxamide 97%
25 g
$ 472.00

Crysdot
4-Chloro-7-methoxyquinoline-6-carboxamide 95+%
100g
$ 832.00

Crysdot
4-Chloro-7-methoxyquinoline-6-carboxamide 95+%
25g
$ 277.00

Chemenu
4-chloro-7-methoxyquinoline-6-carboxamide 95%
25g
$ 262.00

Chemenu
4-chloro-7-methoxyquinoline-6-carboxamide 95%
10g
$ 143.00

Biosynth Carbosynth
4-Chloro-7-methoxyquinoline-6-carboxamide
500 mg
$ 45.00

Biosynth Carbosynth
4-Chloro-7-methoxyquinoline-6-carboxamide
1 g
$ 75.00

Biosynth Carbosynth
4-Chloro-7-methoxyquinoline-6-carboxamide
2 g
$ 120.00

Total 130 raw suppliers

Chemical Property of 4-chloro-7-Methoxyquinoline-6-carboxaMide

Chemical Property:

Melting Point:>205°C (dec.)
Boiling Point:426.7±45.0 °C(Predicted)
PKA:15.28±0.30(Predicted)
PSA：66.20000
Density:1.380±0.06 g/cm3(Predicted)
LogP:2.87990
Storage Temp.:under inert gas (nitrogen or Argon) at 2-8°C
Solubility.:DMSO (Slightly), Methanol (Slightly)

Purity/Quality:

99% ^*data from raw suppliers

4-Chloro-7-methoxy-6-quinolinecarboxamide ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Uses Pharmaceutical Intermediates. 4-chloro-7-Methoxyquinoline-6-carboxaMide is used as an intermediate for synthesizing Lenvatinibis.

Technology Process of 4-chloro-7-Methoxyquinoline-6-carboxaMide

There total 1 articles about 4-chloro-7-Methoxyquinoline-6-carboxaMide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 67608-58-6
4-cyano-3-hydroxy-aniline

: 417721-36-9
4‐chloro‐7‐methoxyquinoline‐6‐carboxamide

Guidance literature:: Multi-step reaction with 5 steps

1: tetrabutylammomium bromide; potassium carbonate / N,N-dimethyl-formamide / 9 h / 110 °C

2: ethanol / 6 h / Reflux

3: polyphosphoric acid / 9 h / 100 °C

4: thionyl chloride / 6 h / Reflux

5: acetic acid / water / 23 h / 90 °C

With thionyl chloride; tetrabutylammomium bromide; potassium carbonate; acetic acid; In ethanol; water; N,N-dimethyl-formamide;

Reference yield: 98.8%

: 417721-36-9
4‐chloro‐7‐methoxyquinoline‐6‐carboxamide

: 17609-80-2
4-amino-3-chlorophenol

: 417722-93-1
4?(4?amino?3?chlorophenoxy)?7?methoxyquinoline?6?carboxamide

Guidance literature:: With potassium hydroxide; In dimethyl sulfoxide; at 65 - 70 ℃; for 2h; Temperature; Reagent/catalyst; Solvent; Concentration; Inert atmosphere; Large scale;