417725-79-2Relevant academic research and scientific papers
Enantioselective addition of ketene silyl acetals to nitrones catalyzed by chiral titanium complexes. Synthesis of optically active β-amino acids
Murahashi, Shun-Ichi,Imada, Yasushi,Kawakami, Toru,Harada, Kazuhito,Yonemushi, Yoshiharu,Tomita, Naomi
, p. 2888 - 2889 (2002)
A chiral titanium complex, Ti(O-i-Pr)4/BINOL/tert-butylcatechol, catalyzes enantioselective addition reaction of ketene silyl acetals to nitrones to give optically active β-amino acid derivatives which are biologically active compounds and useful synthetic intermediates of natural products and pharmaceuticals such as β-lactam antibiotics. The combined process of catalytic oxidation of secondary amines and enantioselective carbon-carbon bond formation of nitrones thus obtained with ketene silyl acetals provides a useful two-step method for the synthesis of optically active β-amino acid derivatives and related nitrogen compounds. Copyright
