41776-15-2Relevant articles and documents
Easer and dithiocarbamate-containing mercaptopyrimidine derivative and preparation and application thereof
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Paragraph 0048; 0049, (2019/10/01)
The invention provides an ester and dithiocarbamate-containing mercaptopyrimidine derivative and preparation and application thereof. A preparation method specifically comprises the steps that firstly, a dialkyl amine and a carbon disulfide form dithiocarbamate salt under the alkaline condition, and then 4,6-dimethyl-2-thiopyrimidine reacts with chloropropanol, chloroacetyl chloride and dithiocarbamate salt to obtain the pyrimidine derivative lubricating oil additive as shown in the general formula I. the derivative has the advantages that the preparation method is simple, the process condition is mild, the raw materials are easy to obtain, the synthesis cost is low, and the synthesis yield is high; the prepared pyrimidine derivative lubricating oil additive can serve as an extreme pressure, anti-wear, anti-friction and anti-corrosion additive of lubricating oil, the bearing capacity of base oil can be obviously improved, the anti-wear and anti-friction performance is improved, and theadditive is an environment-friendly multifunctional lubricating oil additive.
Dithiocarbamates: Efficient metallo-β-lactamase inhibitors with good antibacterial activity when combined with meropenem
Wang, Ming-Ming,Chu, Wen-Chao,Yang, Yi,Yang, Qian-Qian,Qin, Shang-Shang,Zhang, En
supporting information, p. 3436 - 3440 (2018/09/29)
The activity of β-lactam antibiotics is compromised by metallo-β-lactamases (MBLs). Herein, a series of dithiocarbamate derivatives were designed and synthesized. Their antibacterial activities were tested in combination with meropenem (MEM) against several MBL (NDM and IMP type)-producing clinical isolates. Clinical isolates harboring NDM-1 and IMP-4 became susceptible to MEM when it was combined with dithiocarbamate compounds 4a, 4b or 4f synthesized in this work. Compounds 4a and 4b increased the effectiveness of MEM by up to 2560 times against strains. In vitro bactericidal dynamics tests showed that bacteria died within 24 h when they were treated with compound 4f + MEM. Compounds 4a, 4b and 4f were non-hemolytic and exhibited low toxicity toward HeLa cells in vitro. These data show that compounds containing dithiocarbamate functional group may be helpful in the development of MBL inhibitors.
