4179-25-3

Upstream product

• 164921-78-2 (E)-5-Acetoxy-4-(2-methoxy-4-methyl-phenyl)-pent-2-enoic acid methyl ester 
• 170423-72-0 methyl (4S)-(2-methoxy-4-methylphenyl)pentanoate 
• 170423-70-8 (S)-5-Hydroxy-4-(2-methoxy-4-methyl-phenyl)-pentanoic acid methyl ester 
• 170423-66-2 methyl (4S)-(2-methoxy-4-methylpenyl)-5-hydroxypentanoate 
• 170423-71-9 methyl (4S)-(2-methoxy-4-methylphenyl)-5-tosyloxypentanoate 
• 395080-33-8 (S)-4-(4-Methyl-2-trifluoromethanesulfonyloxy-phenyl)-pentanoic acid methyl ester 
• 1461-10-5 (S)-3-(4-methylphenyl)-1-butanol 
• 4294-57-9 para-methylphenylmagnesium bromide 
• 503543-30-4 (R)-1-(1-bromopropan-2-yl)-4-methylbenzene 
• 1257661-37-2 (S)-1-methyl-4-(pent-4-en-2-yl)benzene 
• 3241-74-5 (S)-4-p-tolylpentanal 
• 1413723-28-0 diethyl 2-(2-(p-tolyl)propyl)malonate 
• 122091-54-7 (R)-(+)-2-(4-methylphenyl)propanol 
• 127393-68-4 (R)-2-(p-tolyl)propane-1,2-diol 

Downstream Products

• 4179-26-4 (+)-(S)-4-p-Tolyl-pentansaeure-ethylester 
• 4179-29-7 (+)-(S)-2-Methyl-6-p-tolyl-heptan-2-ol 
• 93742-08-6 (+)-(S)-2-Methyl-6-p-tolyl-2-chlor-heptan 
• 19876-64-3 (S)-(+)-4-p-tolylpentan-1-ol 
• 4179-28-6 (+)-(S)-1-Brom-4-p-tolyl-pentan 

Relevant academic research and scientific papers

Asymmetric synthesis of (R)-ar-curcumene, (R)-4,7-dimethyl-l-tetralone, and their enantiomers via cobalt-catalyzed asymmetric Kumada cross-coupling

An efficient and concise asymmetric synthesis of (R)-(+)-ar-curcumene, (R)-4,7-dimethyl-l-tetralone, and their enantiomers was accomplished. The key step to construct the stereogenic benzylmethyl centers of these natural products is the cobalt-catalyzed a

Enantioselective copper-catalyzed conjugate addition of trimethylaluminum to β,γ-unsaturated α-ketoamides: Efficient access to γ-methyl-substituted carbonyl compounds

Picture perfect: By using the reagent trimethylaluminium and β,γ-unsaturated α-ketoamides, 1,4-adducts were obtained with perfect 1,4-regioselectivity and good to excellent yields and ee values. The potential synthetic utility of the methodology was highl

Enantioselective synthesis of the essential oil and pheromonal component ar-himachalene by a chiral pool and chirality induction approach

The enantioselective synthesis of both isomers of ar-himachalene has been achieved starting from enantiomerically pure citronellal and p-methyl α-methyl styrene as an application of a chiral pool and chirality induction approach, respectively. The key reactions involved in the synthesis include the Sharpless asymmetric dihydroxylation for the induction of chirality at benzylic carbon bearing the methyl group and the use of a hypervalent iodine reagent or trimethylsilyldiazomethane (TMSCHN2) for the six to seven membered ring expansion.

Total synthesis of (S)-(+)-curcudiol, and (S)-(+)- and (R)-(-)-curcuphenol1)

A highly enantioselective synthesis of the versatile chiral synthons possessing one stereogenic center, (S)-and (R)-4-aryl-5-hydroxy-(2E)-pentenoate (3) was achieved based on the enzymatic reaction of (±)-3 with commercially available lipases MY-30 or OF-360 from Candida rugosa. Application of (S)-3 and (R)-3 to the total syntheses of (S)-curcuphenol (1), (S)-curcudiol (2), and (R)-curcuphenol (1), respectively, is described.