41790-73-2

Usage

Uses

Used in Organic Synthesis:
2-(2-OXOPYRROLIDIN-1-YL)BENZOIC ACID is used as a building block for the synthesis of other biologically active compounds. Its unique structure allows for the creation of various organic molecules with potential applications in different industries.
Used in Pharmaceutical Research:
2-(2-OXOPYRROLIDIN-1-YL)BENZOIC ACID is used as a research compound in the pharmaceutical industry for its potential biological activity. It may have applications in the development of new drugs, contributing to the advancement of medicine and treatment options for various conditions.
Used in Drug Discovery and Development:
2-(2-OXOPYRROLIDIN-1-YL)BENZOIC ACID is used as a key component in understanding the structure-activity relationship in drug discovery and development. Its properties and interactions with other molecules can provide valuable insights for the design and optimization of new pharmaceutical agents.

InChI:InChI=1/C11H11NO3/c13-10-6-3-7-12(10)9-5-2-1-4-8(9)11(14)15/h1-2,4-5H,3,6-7H2,(H,14,15)

Upstream product

• 24059-71-0 1-(2-methylphenyl)pyrrolidin-2-one 
• 41790-74-3 2-(4-Chloro-butyrylamino)-benzoic acid 
• 22462-26-6 methyl 2-(2-oxo-pyrrolidin-1-yl)benzoate 
• 22462-27-7 N-<4-Chlor-butyryl>-anthranilsaeuremethylester 
• 4641-57-0 1-phenylpyrrolidin-2-one 
• 201230-82-2 carbon monoxide 
• 95-53-4 o-toluidine 
• 134-20-3 2-carbomethoxyaniline 

Downstream Products

• 1107664-34-5 methyl 2-[2-(2-oxo-pyrrolidin-1-yl)-benzoylamino]-thiophene-3-carboxylate 
• 865190-71-2 C₁₉H₁₈N₂O₄ 
• 1107664-37-8 methyl 5-bromo-2-[2-(2-oxo-pyrrolidin-1-yl)-benzoylamino]-benzoate 

Relevant academic research and scientific papers

Synthetic applications of Pd(II)-catalyzed C-H carboxylation and mechanistic insights: Expedient routes to anthranilic acids, oxazolinones, and quinazolinones

A Pd(II)-catalyzed reaction protocol for the carboxylation of ortho-C-H bonds in anilides to form N-acyl anthranilic acids has been developed. This reaction procedure provides a novel and efficient strategy for the rapid assembly of biologically and pharmaceutically significant molecules, such as benzoxazinones and quinazolinones, from simple anilides without installing and removing an external directing group. The reaction conditions are also amenable to the carboxylation of N-phenyl pyrrolidinones. A monomeric palladacycle containing p-toluenesulfonate as an anionic ligand has been characterized by X-ray crystallography, and the crucial role of p-toluenesulfonic acid in the activation of C-H bonds in the presence of carbon monoxide is discussed. Identification of two key intermediates, a mixed anhydride and benzoxazinone formed by reductive elimination from organometallic Ar(CO)Pd(II)-OTs species, provides mechanistic evidence for a dual-reaction pathway.

Parallel synthesis and spectroscopic analysis of a collection of heterocycles based on the diazabenz[e]aceanthrylene core structure

A practical strategy for the synthesis of diazabenz[e]aceanthrylene-based heterocycles is reported. The key step in this approach is a microwave-assisted condensation and cyclisation reaction between an anthranilic acid derivative and a 2′-carbomethoxy substituted N-aryl lactam. The scope of the reaction has been explored as a function of both the nature and position of substituents in both components and variations in lactam ring size. Interesting structural and spectroscopic variations observed across the compound collection are described and explored using NMR, X-ray crystallography and computational techniques.

Synthesis of a new family of N-aryl lactams active on chemesthesis and taste

A new class of synthetic compounds with chemesthetic activity has been identified. They have been designed ex-novo by structural similarity with known cooling compounds such as menthol, icilin and cyclic ketoenamines. 19 new derivatives have been obtained