41790-94-7Relevant academic research and scientific papers
Cobalt-catalyzed ortho-alkenylation of aromatic aldimines via chelation-assisted C-H bond activation
Yamakawa, Takeshi,Yoshikai, Naohiko
, p. 4459 - 4465 (2013/06/26)
An ortho-alkenylation reaction of an aromatic aldimine with an internal alkyne is efficiently promoted by a cobalt catalyst generated from CoBr 2, triarylphosphine, and iPrMgBr. The reaction takes place under mild room-temperature co
Regioselective synthesis of substituted naphthalenes and phenanthrenes by FeCl3-promoted annulation of aryl and naphthyl acetaldehydes with alkynes
Bu, Xiuli,Hong, Longcheng,Liu, Ruiting,Hong, Jianquan,Zhang, Zhengxing,Zhou, Xigeng
experimental part, p. 7960 - 7965 (2012/09/21)
The FeCl3-promoted annulation reaction of aryl acetaldehydes with alkynes has been established, which provides a new and versatile straightforward procedure for the regioselective synthesis of mono-, di-, and polysubstituted naphthalenes under mild conditions. Interestingly, the present catalytic system not only differentiates between internal and terminal alkynes but also shows unprecedented complete Me3SiOH elimination selectivity for silyl alkyne substrates. Furthermore, the synthesis of a series of substituted phenanthrenes via reactions of nathphyl acetaldehydes with internal alkynes is also achieved for the first time in good yields with excellent regioselectivity.
