41799-31-9

Basic information

• Product Name: 1-chloro-4-hydroxydibenzofuran
• Synonyms: 1-chloro-4-hydroxydibenzofuran
• CAS NO: 41799-31-9
• Molecular Formula: C12H7ClO2
• Molecular Weight: 218.63578
• Mol File: 41799-31-9.mol
• Article Data: 1

Chemical Properties

• Melting Point: 150 - 151 °C
• CAS DataBase Reference: 1-chloro-4-hydroxydibenzofuran(CAS DataBase Reference)
• NIST Chemistry Reference: 1-chloro-4-hydroxydibenzofuran(41799-31-9)
• EPA Substance Registry System: 1-chloro-4-hydroxydibenzofuran(41799-31-9)

Safety Data

• Hazardous Substances Data: 41799-31-9(Hazardous Substances Data)

Upstream product

• 953-18-4 S-benzyl-L-cysteine ethyl ester 
• 101762-29-2 1-chloro-4-(benzyloxycarbonyl-L-alanyloxy)dibenzofuran 
• 101762-28-1 1-chloro-4-acetoxydibenzofuran 

Downstream Products

• 101762-29-2 1-chloro-4-(benzyloxycarbonyl-L-alanyloxy)dibenzofuran 

Relevant articles and documents

Peptide Synthesis by Prior Thiol Capture. 2. Design of Templates for Intramolecular O,N-Acyl Transfer. 4,6-Disubstituted Dibenzofurans as Optimal Spacing Elements

A central feature of the strategy for amide bond formation by prior thiol capture is an intramolecular acyl transfer across a template that links the phenolic ester function of one peptide with an unsymmetrical disulfide involving the side chain of the N-terminal cysteine residue of a second peptide.The structures of the 4-hydroxy-6-mercaptodibenzofuran (3) and 4-hydroxy-6-mercaptophenoxythiin (4) are established by 1H NMR spectra of deuterated dibenzofuran and phenoxythiin derivatives.On the basis of the criterion of effective molarity, a dibenzofuran template for intramolecular acyl transfer is shown to be approximately 2 orders of magnitude more efficient than a phenoxythiin.An effective local concentration of ca. 5 M and a Hammett ρ value of 2.6 are observed for the intramolecular acyl-transfer reaction 1 -> 2.