41803-45-6Relevant academic research and scientific papers
Studies on the Preparation of Dihydro-1,4-oxathiines. Computer-Assisted Evaluation of the Results of Retrosynthetic Analysis Verified by Synthetic Experiments and By-Product Analyses. Synthetic Pathways Involving α-Sulfenylated Ketones and 1,3-Oxathiolanes of α-Halo and α-Hydroxy K...
Nevalainen, Vesa,Pohjala, Esko,Maelkoenen, Pentti,Hukkanen, Heikki
, p. 591 - 602 (2007/10/02)
The preparation of 2- and 2,3-substituted 5,6-dihydro-1,4-oxathiines has been studied by computer simulation and by experiment.Three major synthetic pathways, involving 2-(1-hydroxyalkyl)-1,3-oxathiolanes, 2-(1-haloalkyl)-1,3-oxathiolanes, 2-hydroxyethylthiomethyl ketones, methanesulfonates of 2-hydroxyethylthiomethyl ketones and 2-choroethylthiomethyl ketones as intermediates, were evaluated, by running the program CAMEO, and by experiment.The results of the two approaches were compared and the major by-products of the reactions were identified by GLC/MS.
Studies on the Formation of Dihydro-1,4-oxathiines by Halogenation of 1,3-Oxathiolanes.
Nevalainen, Vesa,Pohjala, Esko
, p. 1401 - 1421 (2007/10/02)
Formation of 5,6-dihydro-1,4-oxathiines (1a-g) by halogenation of 1,3-oxathiolanes (4a-g) was investigated.Moderate yields of (1) were obtained in systems in which the newly formed double bond of the heterocyclic ring was stabilised by conjugation.In addition to the dihydro-1,4-oxathiines (1a-g), their halogenated derivatives and some fused and spiro 1,4-oxathianes were produced as by-products.By-products of reactions were analysed by gas chromatography and mass-spectrometry.
